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Sickle Cell Disease

Paperback Engels 2021 9781260458596
€ 177,38
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The most comprehensive, current sickle cell disease resource—for both clinicians and researchers

A Doody's Core Title for 2024 & 2023!

The first and only resource of its kind, Sickle Cell Disease examines this blood disorder through both clinical and research lenses. More than 80 dedicated experts in the field present their combined clinical knowledge of basic mechanisms, screening, diagnosis, management, and treatment of myriad complex complications of a single base point mutation in the human genome. Case studies with “How I Treat” authoritative insights provide overviews of common and rare complications, and Key Facts offer at-a-glance high-yield information. 

Filled with clinical photos, illustrations, numerous original diagrams, and with free updates available online, this unmatched resource covers:
Mechanisms of sickle cell diseaseHistoric and current research approachesThe latest work in gene therapy and editingGuidelines for patient care, diagnosis, unique cases, and therapiesRare and common complications, including domestic and internationally relevant topicsPsychosocial and supportive careThe newest standards of therapy and future treatment options in children and adultsCardiopulmonary complicationsA Doody's Core Title for 2022!

 

Specificaties

ISBN13:9781260458596
Taal:Engels
Bindwijze:paperback

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<strong><p>Table of Contents</p><p>I. Basic Mechanisms of Disease:</p></strong><p>1. Overview: Carlo Brugnara, Betty Pace</p><p>2. Genetic basis of SCD: Martin Steinberg, SweeLay Thein</p><p>3. Hemoglobin S polymerization: Daniel Kim-Shapiro, Alan Schechter, and Constance Noguchi</p><p>4. Adhesion and vaso-occlusion - the role of leukocytes: Paul Frenette, </p><p>5. Hemolysis and endothelial dysfunction: Mark Gladwin, Gregory Kato</p><p>6. Sterile inflammation and the inflammasome: Prithu Sundd, Solomon Ofori-Acquah</p><p>7. IIschemia-reperfusion injury, inflammation and oxidative stress: Robert Hebbel, John Belcher, Gregory Vercellotti</p><p>8. Mouse models of SCD and mechanisms of pain:Cheryl Hillery, Kalpna Gupta, Lewis Hsu</p><p>9. Fetal hemoglobin induction - past, present and future: Abdullah Kutlar, Griff Rodgers</p><strong><p>II. Clinical Complications of Sickle Cell Disease:</p></strong><p>Overview: Alexis Thompson, Ken Ataga</p><p>10. Stroke and cognitive dysfunction: Fenella Kirkham, Michael DeBaun, Robert Adams</p><p>11. Pediatric complications and newborn screening: John J. Strouse, James Casella, Nancy Green</p><p>12. Airway hyperreactivity and asthma: Claudia Morris, Liz Klings</p><p>13. Acute chest syndrome:Elliott Vichinsky, Armand Mekontso-Dessap</p><p>14. Pulmonary hypertension (PH) and critical illness: Roberto Machado, Mark Gladwin</p><p>15. Heart disease: Vandana Sachdev, Punam Malik,John Wood</p><p>16. Renal: Victor Gordeuk,Santosh Saraf, Jane Little</p><p>17. Sickle cell trait: Philippe Connes, Rakhi Naik, Hyacinth Hyacinth</p><p>18. Thrombophilia in SCD: Nigel Key, Rafal Pawlinski, Enrico Novelli</p><p>19. Acute and chronic pain: Wally Smith, Samir Ballas</p><p>20. “Orphan” complications - leg ulcers and priapism: Caterina Minniti, Arthur Burnett</p><p>21. Ocular complications: : Adrienne Scott, Morton Goldberg</p><p>22. Rare presentations and emerging complications: Frédéric Galacteros, Oswaldo Castro, Kathryn Hassell</p><p>23. Globalburden of disease: new frontiers in SCD research and care: Kwaku Ohene-Frempong, Julie Makani, Fernando Costa, Graham Serjeant,Yazdi Italia</p><strong><p>III. EmergingTherapeutics:</p></strong><p>Overview: David Rees, Sophie Lanzkron</p><p>24. Transfusion medicine: Anoosha Habibi, Darrell Triulzi, Miguel Abboud, Sally Campbell Lee</p><p>25. Clinical trials - state of the art and lessons learned: Ken Ataga, Laura De Castro, Marilyn Telen </p><p>26. Stem cell transplantation: John Tisdale,Courtney Fitzhugh, Mark Walters, Lakshmanan Krishnamurti</p><p>27. Emergency care – challenges and opportunities: ClaudiaMorris</p><p>28. The psychosocial burden in SCD: MarciaTreadwell, Allison King, Julie Panepinto, Charles Jonaissant</p><p>29. Hydroxyurea and the dawn of combination therapy in SCD: Winfred Wang, Russell Ware</p><p>30. <strong>The HOLY GRAIL - Gene editing and Therapy</strong>: TimTownes, Marina Cavazzana-Calvo</p><p>Additional authors:</p><p>Joshua Field (chapter assignment TBD)</p><p></p>

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€ 177,38
Levertijd ongeveer 11 werkdagen
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