Structure and Function of the Neural Cell Adhesion Molecule NCAM

Structure and Ligands of NCAM.- Structural Biology of NCAM.- Extracellular Protein Interactions Mediated by the Neural Cell Adhesion Molecule, NCAM: Heterophilic Interactions Between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses.- Intracelluar Ligands of NCAM.- NCAM and the FGF-Receptor.- The Role of ATP in the Regulation of NCAM Function.- NCAM and Polysialic Acid.- Polysialylation of NCAM.- Structural Basis for the Polysialylation of the Neural Cell Adhesion Molecule.- The Role of PSA-NCAM in Adult Neurogenesis.- Use of PSA-NCAM in Repair of the Central Nervous System.- NCAM-mediated Signal Transduction.- Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth.- Role of the Growth-Associated Protein GAP-43 in NCAM-Mediated Neurite Outgrowth.- The Neural Cell Adhesion Molecule NCAM and Lipid Rafts.- The Neural Cell Adhesion Molecule and Epidermal Growth Factor Receptor: Signaling Crosstalk.- NCAM Metabolism.- Biosynthesis of NCAM.- Soluble NCAM.- NCAM, Synapses, Emotions, and Memory.- Role of NCAM in Spine Dynamics and Synaptogenesis.- NCAM in Long-Term Potentiation and Learning.- Role of NCAM in Emotion and Learning.- NCAM in Disease.- NCAM in Neuropsychiatric and Neurodegenerative Disorders.- Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms.- Pharmacology of NCAM: NCAM Mimetics.- NCAM Mimetic Peptides: An Update.- Synthetic NCAM-Derived Ligands of the Fibroblast Growth Factor Receptor.- Dendritic Spine and Synapse Morphological Alterations Induced by a Neural Cell Adhesion Molecule Mimetic.- Orthologs and Paralogs of NCAM.- Fasciclin II: The NCAM Ortholog in Drosophila melanogaster.- The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM, a Close Relative to NCAM.- Conclusion.- Honoring Dr. Elisabeth Bock.