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Drug Metabolism and Pharmacokinetics Quick Guide

Paperback Engels 2011 2011e druk 9781441956286
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Specificaties

ISBN13:9781441956286
Taal:Engels
Bindwijze:paperback
Aantal pagina's:214
Uitgever:Springer New York
Druk:2011

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Inhoudsopgave

Pharmacokinetics.- Drug Metabolizing Enzymes.- Oral Absorption.- Transporters.- Metabolism-Based Drug Interactions.- Biotransformation and Bioactivation.- Prediction of Human Pharmacokinetics.- Advances in Bioanalysis as it Relates to ADME.- ADME Properties and Their Dependence on Physicochemical Properties.- In Silico ADME Tools.- Approved Drugs.- Chemical Nomenclature.

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        Drug Metabolism and Pharmacokinetics Quick Guide