Alzheimer Disease

I. Pathological Basis of Therapy in Alzheimer’s Disease.- Criteria for the Diagnosis of Alzheimer’s Disease.- Neuropathology Of Alzheimer’s Disease.- Processing of Amyloid, Cytoskeletal Damage and Apolipoproteins.- Cell Death: Excitotoxins, Apoptosis And Hypometabolism.- Neurotrophins, Growth Factors and Neuroprotectors.- Animal Models.- II. The Cholinergic System in Brain.- Treatment of Alzheimer Disease.- Cholinesterase Inhibitors in Alzheimer Disease Treatment.- III. Nicotinic and Muscarinic Cholinergic Agonists.- Nicotinic Agonists.- Muscarinic Agonists and Antagonists.- The Potential of Antioxidant Therapy.- The Potential for Anti-Inflammatory Therapy.- IV. Development of New Therapies in Alzheimer Disease.- Design of Clinical Trials.- Advances in Assessment.- SPECT and PET.- Potential Markers of Disease Progression and Drug Efficacy in Alzheimer’s Disease.- Treatment of Behavioral and Psychosocial Disturbances.- V. Social Issue in Alzheimer Disease.- Legal and Ethical Issues.- Socio-Economic As pects of Alzheimer Disease Treatment.- International Harmonization of Drug Guidelines.- Research Priorities in Alzheimer Disease Treatment — An International Perspective.- Author Index.