Evolutionary Systems Biology

Preface.- Evolutionary Systems Biology: Historical and Philosophical Persepctives on an Emerging Synthesis.- Metabolic Networks and their Evolution.- Organization Principles and their Evolution.- Organization principles in genetic interaction networks.- Evolution of regulatory networks: Nematode vulva induction as an example of developmental systems drift.- Life’s attractors understanding developmental systems through reverse engineering and in silico evolution.- Evolutionary characteristics of bacterial two-component systems.- Comparative interaction networks - bridging genotype to phenotype.- Evolution in silico: from network structure to bifurcation theory.- On the search for design principles in biological systems.- Towards a theory of multilevel evolution; long term information integration shapes the mutational landscape and enhances evolvability.- Evolutionary principles underlying structure and response dynamics of cellular networks.- Phenotypic plasticity and robustness: Evolutionary stability theory, gene expression dynamics model, and laboratory experiments.- Genetic redundancies and their evolutionary maintenance.- Evolution of resource and energy management in biologically realistic gene regulatory network models.- Reverse ecology: From systems to environments and back.- Bacteria-virus coevolution.- The genotype-phenotype maps of systems biology and quantitative genetics: distinct and complementary.- How evolutionary systems biology will help understand adaptive landscapes and distributions of mutational effects.- Building synthetic systems to learn Nature’s design principles.- The robustness continuum.- Index.