Pierre Hainaut,
Magali Olivier,
Klas G. Wiman
p53 in the Clinics
Gebonden Engels 2012 2013e druk 9781461436751Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into the clinics. The goal of this book is to capture these developments and to appeal to a clinical and medical audience beyond the one which was the primary target of "25 years of p53".
Specificaties
ISBN13:9781461436751
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:358
Uitgever:Springer New York
Druk:2013
Lezersrecensies
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Inhoudsopgave
Foreword.- p53 activities and the hallmarks of cancer.- The inheritance of p53.- p53: Guardian of the metabolome.- The p53 family and stem cell biology.- Mutant p53-driven tumorigenesis.- Humanized p53 mouse models.- p53 models for mammary carcinogenesis.- TP53 somatic mutations: Prognostic and predictive value in human cancers.- Assessing TP53 status in human tumors - lessons from breast cancer.- TP53 germline mutations: Genetics of Li-Fraumeni Syndrome.- TP53 gene therapy.- Upstream targets in the p53 pathway.- p53-reactivating molecules as research tools and anti-cancer drugs.- Restoring mutant p53 activity.- p53-immunotherapy of cancer.- Designing p53 trials: a surgical oncologist view.- p53 in the clinic: a pathologist view.- p53 in genetic counseling.- Index.
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