Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

Introduction.- Bacterial genomes and vaccine design.- Identification of candidate vaccine antigens in silico.- Post-Genomic Antigen Discovery: Bioinformatical Approaches to Reveal Novel T-Cell Antigens of Mycobacterium Bovis.- Genome-based Computational Vaccine Discovery by Reverse Vaccinology.- Computational prediction of protein subcellular localization, genomic islands, and virulence to aid antigen discovery.- On the development of Vaccine Antigen Databases: Progress, Opportunity, and Challenge.- What have Dendritic Cells ever done for adjuvant design?  Cellular and Molecular Methods for the Rational Development of Vaccine Adjuvants.- Towards the Rational Discovery of Adjuvants.- Designing liposomes as vaccine adjuvants.- Enhancing the delivery and potency of antigens using non-ionic based vesicles.- Immune stimulating complexes (ISCOMs) and Quil-A containing particulate formulations as vaccine delivery systems.- Formulation and characterisation of PLGA microspheres as vaccine adjuvants.- Powder Vaccines for Pulmonary Delivery.