Kevin M. Haigis, Ph.D.
Molecular Pathogenesis of Colorectal Cancer
Gebonden Engels 2013 2013e druk 9781461484110
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Specificaties
ISBN13:9781461484110
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:316
Uitgever:Springer New York
Druk:2013
Lezersrecensies
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Inhoudsopgave
Preface.- The Genetics of Colorectal Cancer.- Molecular Mechanisms of Colorectal Carcinogenesis.- The association between inflammation and colorectal cancer.- Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease.- Mutational activation of KRAS and BRAF in colorectal cancer.- The PI3K pathway in Colorectal Cancers.- TGF-ß signaling pathway and colorectal cancer.- The Clinical Significance of Mutations in Colorectal Cancer.- Colorectal Cancer Genome and Its Implications.- Copy-Number Alterations in the Colorectal Cancer Genome.- Genome-wide association studies in colorectal cancer.- Future prospects for leveraging molecular information in the fight against colorectal cancer.- Index.
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