Progress in Polyamine Research

Ornithine Decarboxylase: Molecular Genetics, Post-Synthetic Modifications and Antizyme.- Androgen Regulation of Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase Gene Expression.- Regulation of Polyamine Biosynthesis in Escherichia coli by the Acidic Antizyme and the Ribosomal Proteins S20 and L34.- Studies on Ornithine Decarboxylase Antizyme.- Ornithine Decarboxylase Antizyme in Mammalian Tissues.- Phosphorylation by Casein Kinase-2 and Reversible Alteration of Thiol Groups: Mechanisms of Control of Ornithine Decarboxylase?.- Modifications of Ornithine Decarboxylase induced by Phosphatases.- Enzymes of Polyamine Metabolism and Recycling.- S-Adenosylmethionine Decarboxylase from Escherichia coli and from Saccharomyces cerevisiae: Cloning and Overexpression of the Genes.- Structural and Mechanistic Properties of E. coli Adenosylmethionine Decarboxylase.- S-Adenosylmethionine Decarboxylase from the Thermophilic Archaebacterium Sulfolobus solfataricus.- Properties of Human and Rodent S-Adenosylmethionine Decarboxylase.- Aminopropyltransferases: Mechanistic Studies and the Synthesis of Specific Inhibitors.- Approaching the Structures of Mammalian Propylamine Transferases and their Genes.- Potential Roles of Polyamine Interconversion in the Mammalian Organism.- The Biological Functions of Amine Oxidases and their Reaction Products: an Overview.- Metabolism of 5? -Methylthioadenosine in Normal and Transformed Cells.- Human 5?-Deoxy-5?-Methylthioadenosine Phosphorylase: Kinetic Studies and Catalytic Mechanism.- Methylthioadenosine (MeSAdo) Phosphorylase Deficiency in Malignancy.- Physico-Chemical and Immunological Properties of Bovine Liver 5?-Deoxy-5?-Methylthioadenosine Phosphorylase.- Exploitation of Methylthioribose Kinase in the Development of Antiprotozoal Drugs.- MTA Phosphorylase in Protozoa: a Potential Target for Chemotherapeutic Attack.- Characterization and Biogenesis of 5?-Methylthioxylofuranosyl Adenine, a New Natural Analog of 5?-Methylthioadenosine.- Studies on Human Serum 5?-Deoxy-5?-Methylthioadenosine Phosphorylase: Molecular Properties and Clinical Perspectives.- Polyamines in Cell Growth and Differentiation.- Growth Regulation of the Cellular Levels and Expression of the mRNA Molecules coding for Ornithine Decarboxylase and Adenosylmethionine Decarboxylase.- Structure, Amplification and Methylation of Ornithine Decarboxylase Genes in Human Malignant Cells.- Regulation of Polyamine Synthesis in Mammalian Cells.- Mechanisms Involved in Ornithine Decarboxylase Induction by 12-0-Tetradecanoylphorbol-13-acetate, a Potent Mouse Skin Tumor Promotor and an Activator of Protein Kinase C.- Polyamines, DNA Methylation and Cell Differentiation.- Two Phases of Ornithine Decarboxylase Activation during Lymphocyte Mitogenesis.- Regulation of Protein Synthesis by Polyamines.- Polyamine Recycling Enzymes in Human Cancer Cells.- Estrogenic Control of Spermidine/Spermine N1-Acetyltransferase Activity in Rat Uterus.- Erythrocyte Polyamines: their Diagnostic and Therapeutic Importance in Human Neuro-Oncology.- Abnormalities of Polyamine Biosynthesis in Spinal Cord of Totally Gastrectomized Rats.- Ornithine Decarboxylase and Polyamine Biosynthesis in Pancreatic Adaptation.- Post-Synthetic Modifications of Proteins Involving Polyamines.- Transglutaminases and their Regulation: Implications for Polyamine Metabolism.- Purification and Structural Characterization of in vitro Synthesized (?-Glutamyl)Spermidine Conjugates of a Major Protein Secreted from the Rat Seminal Vesicles.- Covalent Polyamine-Protein Conjugates: Analysis and Distribution.- Spermidine in Mammalian Lymphocytes and Sea Urchin Embryos: Uptake and Labeling of Macromolecules.- Biosynthesis of Hypusine in eIF-4D Precursors.- Hypusine Biosynthesis in Protein and its Biological Consequences.- Deoxyhypusine Hydroxylase.- Intractions of Polyamines with Macromolecules.- Effect of Polyamines on Protein Kinase C Activation Process.- Interaction of Polyamines with Phospholipids, Spermine and Ca2+ Competition for Phosphatidylserine Containing Liposomes.- Bidirectional Transport of Spermine across the Inner Membrane of Liver Mitochondria.- Polyamines Stimulate the in vitro Transport of the Precursor of Ornithine Carbamoyltransferase into Rat Liver Mitochondria.- Uptake of Polyamines by Human Lymphocytes and their Effect on Lactate Formation from Glucose.- Theoretical and Experimental Characterization of Polyamine/DNA Interactions.- Effect of Spermine on Transfer RNA and Transfer RNA-Ribosome Interactions.- Spermine Inhibition of Basal and Stimulated Adenylate Cyclase is Mediated by the Inhibitory GTP-Binding Protein (Gi).- Polyamines in Plants.- Polyamines as Growth Substances in Higher Plants.- Polyamines in Growth and Differentiation of Plant Cell Cultures: the Effect of Nitrogen Nutrition, Salt Stress and Embryogenic Media.- The Di- and Polyamine Oxidases of Plants.- Control of Phytopathogens by Inhibitors of Polyamine Biosynthesis.- Relationship between Polyamine and Ethylene Biosynthesis in Plants and its Significance in Morphogenesis in Cell Cultures.- Purification of Polyamine Oxidase from Maize Seedlings by Immunoadsorbent Column.- Polyamines in Microorganisms.- Polyamine Pools and the Control of Ornithine Decarboxylase Activity.- Biochemical Properties of Unusual Polyamines found in an Extreme Thermophile, Thermus thermophilus.- Polyamines in the Cell Cycle of the Malarial Parasite Plasmodium falciparum.- The Role of Polyamines in the Growth and Transformation of the African Trypanosome.- The Role of Glutathionylspermidine and Trypanothione in Regulation of Intracellular Spermidine Levels during Growth of C. fasciculata.- Inhibitors of Polyamine Biosynthesis in Therapy.- Regulation of Polyamine Biosynthetic Activity by Spermidine and Spermine Analogs — a Novel Antiproliferative Strategy.- Fluorine-Containing Polyamines: Biochemistry and Potential Applications.- Mechanism of Antitumor Activity of Norspermidine, a Structural Homologue of Spermidine.- The Effects of Polyamine Analogues on Malaria Parasites in vitro and in vivo.- Inhibition of Ornithine or Arginine Decarboxylase as an Experimental Approach to African or American Trypanosomiasis.- The Polyamine Metabolism of Filarial Worms as Chemotherapeutic Target.- Large Bowel Tumor Promotion by Diamine Oxidase Inhibition: Animal Model and Clinical Aspects.- Closing Remarks: Changing Perspectives in Polyamine Research.- Contributors.