Translational Neuroscience

Fundamental Approaches for Neurological Disorders

Gebonden Engels 2016 9781489976529
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Translational Neuroscience offers a far-reaching and insightful series of perspectives on the effort to bring potentially revolutionary new classes of therapies to the clinic, thereby transforming the treatment of human nervous system disorders. Great advances in the fields of basic neuroscience, molecular biology, genomics, gene therapy, cell therapy, stem cell biology, information technology, neuro devices, rehabilitation and others over the last 20 years have generated unprecedented opportunities to treat heretofore untreatable disorders of the nervous system. This book provides a wide-ranging yet detailed sample of many of these efforts, together with the methods for pursuing clinical translation and assessing clinical outcomes. Among the topics covered are Alzheimer’s disease, Parkinson’s disease, stroke, multiple sclerosis, epilepsy, motor neuron disease, pain, inborn errors of metabolism, brain tumors, spinal cord injury, neuroprosthetics, rehabilitation and clinical trial design/consideration.

Translational Neuroscience is aimed at basic neuroscientists, translational neuroscientists and clinicians who seek to gain a perspective on the nature and promise of translational therapies in the current era. Both students and established professionals will benefit from the content.

Specificaties

ISBN13:9781489976529
Taal:Engels
Bindwijze:gebonden
Uitgever:Springer US

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Inhoudsopgave

<p>Chapter 1 - Introduction - Mark H. Tuszynski</p> <p>Section 1: Molecular Approaches</p> <p>Chapter 2 - Gene Therapy of CNS Disorders using Recombinant AAV vectors - Giridhar Murlidharan, R. Jude Samulski and Aravind Asokan</p> <p>Chapter 3 - NGF and BDNF Gene Therapy for Alzheimer’s Disease - Alan H. Nagahara and Mark H. Tuszynski</p> <p>Chapter 4 - GDNF and AADC Gene Therapy for Parkinson’s Disease - Krystof Bankiewicz, Waldy San Sebastian, Lluis Samaranch and John Forsayeth</p> <p>Chapter 5 - GAD Gene Therapy for Parkinson’s Disease - Michael G. Kaplitt and Matthew J. During</p> <p>Chapter 6 - Anti-sense Oligonucleotides</p> for Amyotrophic Lateral Sclerosis - Wade K. Self and Timothy M. Miller<p></p> <p>Chapter 7 - Gene therapy for Inborn Errors of Metabolism: Batten Disease - Dolan Sondhi, Ronald G. Crystal and Stephen M. Kaminsky</p> <p>Chapter 8 - Gene Therapy for Spinal Cord Injury - Ioana Goganau and Armin Blesch</p> <p>Chapter 9 - Gene Therapy for Epilepsy - Thomas J. McCown</p> <p>Chapter 10 - Gene therapy for Pain - Darren Wolfe, David Krisky, James Goss, James Wechuck, Marina Mata and David J. Fink</p> <p>Section 2: Cellular Approaches</p> <p>Chapter 11 - Stem Cells for Parkinson’s Disease - Andrés Bratt-Leal<sup> </sup>and Jeanne F. Loring</p> <p></p>quot;serif"">Chapter 12 - Could Stem Cells be used to treat or model Alzheimer’s Disease? - Edsel M. Abud and Mathew Blurton-Jones<p></p> <p>Chapter 13 - Stem cells for Amyotrophic Late</p><p></p><p></p><p></p><p></p>ral Sclerosis - Anthony Donsante, Lindsey Nicole Urquia and Nicholas M. Boulis<p></p> <p>Chapter 14 - Stem cells for Multiple Sclerosis - Pamela Sarkar and Neil Scolding</p> Chapter 15 - Cell Therapy for Pediatric Disorders of Glia - Joana M. Osorio and Steven A. Goldman<p></p> <p>Chapter 16 - Neural Stem Cells for Spinal Cord Injury - Paul Lu, Ruhel Amhad<sup></sup></p>le="mso-bidi-font-size:12.0pt;font-family:"Times New Roman","serif""> and Mark H. Tuszynski<p></p> <p>Chapter 17 - Marrow-derived Mesenchymal Stromal Cells in the Treatment of Stroke - Steve C. Cramer</p> <p>Chapter 18 - Glioma Stem Cells - Regina Teresa Martuscello, Brent Reynolds<sup> </sup>and Santosh Kesari</p> <p>Section 3: Novel Pharmacological Approaches</p> <p>Chapter 19 - Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer’s Disease - Kevin D. Rynearson, Rudolph E. Tanzi and Steven L. Wagner</p> <p>Chapter 20 - Blocking the Nogo-A signalling pathway to promote regeneration and pla</p>sticity after spinal cord injury and stroke - <p></p>tachment: initial; background-size: initial; background-origin: initial; background-clip: initial; background-position: initial; background-repeat: initial;">Anna Magdalena Guzik-Kornacka, Flóra Vajda, Martin E. Schwab<p></p> <p>Chapter 21 - Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury - Fengfeng Bei and Zhigang He</p> <p>Chapter 22 - Voltage-gated ion channels as molecula</p>r targe<p></p>ts for <p></p>pain - <p></p>Gerald <p></p>W. Zamponi, Chongyang Han<sup> </sup>and Stephen G. Waxman<p></p> <p>Section 4: Activity-Dependent Plasticity and Neurorehabilitation</p> <p>Chapter 23 - Rehabilitation-dependent neural plasticity after Spinal Cord Injury - </p>ot;,"serif"; mso-ansi-language:DE-CH">Volker Dietz, Lea Awai, Armin Curt and Grégoire Courtine<p></p> <p>Chapter 24 - Neural Prostheses for Neurotrauma - Arthur Prochazka</p> <p>Chapter 25 - Why is Fu</p>nctional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? - Mary K. Nagai, Cesar Marquez-Chin and Milos R. Popovic<p></p> <p>Chapter 26 - Deep Brain Stimulation for Neuropsychiatric Disorders - Ausaf A. Bari, Nicolas Kon Kam King, Nir Lipsman and Andres M. Lozano</p> <p>Chapter 27 - Novel Interventions for Stroke: Nervous System Cooling - Patrick D. Lyden, Jessica Lamb and Padmesh S. Rajput</p> <p>Chapter 28 - Rehabilitation Strategies For Restorative Approaches After Stroke and Neurotrauma - Bruce H. Dobkin</p> al">Chapter 29 - Bridging the Chasm Between Scientific Discovery and a Pivotal Clinical Trial for a CNS Disorder: A Checklist - John D. Steeves<p></p> <p>Chapter 30 - Conclusion - Mark H. Tuszynski</p>

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        Translational Neuroscience