Adenosine

Adenosine and metabolism – a brief historical note.- Adenosine metabolism, adenosine kinase and evolution.- Adenosine and energy metabolism - relationship to brain bioenergetics.- Adenosine and autocrine metabolic regulation of neuronal activity.- Physiologic and metabolic regulation of adenosine – mechanisms.- The double edged sword: gaining adenosine at the expense of ATP. How to balance the books.- Downstream pathways of adenosine.- Astrocytic ATP release.- Role of striatal A2A receptor subpopulations in neurological disorder.- Sleep and adenosine: human studies.- Adenosine and Other Purinergic Products in Circadian Timing.- Adenosine in the immune system.- The bioenergetics network of adenosine in hibernation, sleep and thermoregulation.- Adenosine and stroke.- The many roles of adenosine in traumatic brain injury.- Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitutions after Spinal Cord Injury.- Adenosine and pain.- Symptomatic and neuroprotective effects of A_2A receptor antagonists in Parkinson’s Disease.- Adenosine receptors and Alzheimer’s Disease.- Adenosine receptors in Huntington’s Disease.- Adenosine and Multiple Sclerosis.- Adenosinergic perspectives on schizophrenia – Opportunity for an integrative synthesis.- The role of adenosine in the ventral striatal circuits regulating behavioral activation and effort-related decision making: Importance for normal and pathological aspects of motivation.- Adenosine and autism:  Physiological symptoms and metabolic opportunities.- Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes.- Disruption of adenosine homeostasis in epilepsy and therapeutic adenosine augmentation.- Ketogenic Diet and Epilepsy: The Role of Adenosine.- Silk – a biocompatible and biodegradable biopolymer for therapeutic adenosine delivery.- Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy.