Sigma Receptors

Contributing Authors.- Preface.- s Receptors: Historical Perspective and Background.- Medicinal Chemistry: New Chemical Classes and Subtype Selective Ligands.- Irreversible s Compounds.- Pharmacophore Models for s1 Receptor Binding.- Cloning of s1 Receptor and Structural Analysis of its Gene and Promoter Region.- Site-Directed Mutagenesis.- s Receptor Modulation of Ion Channels.- Subcellular Localization and Intracellular Dynamics of s1 Receptors.- Intracellular Signaling and Synaptic Plasticity.- Modulation of Classical Neurotransmitter Systems by s Receptors.- s2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics.- Cognitive Effects of s Receptor Ligands.- s Receptors and Schizophrenia.- Potential Role of s1 Ligands and Neurosteroids in Major Depression.- s Receptors and Drug Abuse.- s1 Receptors and Modulation of Opiate Analgesics.- s Receptors in the Immune System: Implications for Potential Therapeutic Intervention - an Overview.- s Receptors and Gastrointestinal Function.- Appendix.