Retinal Degenerative Diseases

Molecular Genetics and Candidate Genes.- Genetic Factors Modifying Clinical Expression of Autosomal Dominant RP.- Disease-Associated Variants of the Rod-derived Cone Viability Factor (RdCVF) in Leber Congenital Amaurosis.- Leber Congenital Amaurosis: Survey of the Genetic Heterogeneity, Refinement of the Clinical Definition and Phenotype-Genotype Correlations as a Strategy for Molecular Diagnosis.- A First Locus for Isolated Autosomal Recessive Optic Atrophy (ROA1) Maps to Chromosome 8q21-q22.- RCC1-Like Domain and ORF15: Essentials in RPGR Gene.- Choroidal Neovascularization in Patients with Adult-Onset Foveomacular Dystrophy Caused by Mutations in the RDS/Peripherin Gene.- Biochemical Characterisation of the C1QTNF5 Gene Associated with Late-Onset Retinal Degeneration.- Bietti Crystalline Corneoretinal Dystrophy Associated with CYP4V2 Gene Mutations.- Diagnostic, Clinical, Cytopathological and Physiologic Aspects of Retinal Degeneration.- Fundus Appearance of Choroideremia Using Optical Coherence Tomograpy.- A2E, A Fluorophore of RPE Lipofuscin, Can Destabilize Membrane.- Amino-Retinoid Compounds in the Human Retinal Pigment Epithelium.- Annexins in Bruch’s Memberane and Drusen.- Animal Models of Retinal Degeneration.- Molecular Mechanisms of Photoreceptor Degeneration in RP Caused by IMPDH1 Mutations.- Biochemical Function of the LCA Linked Protien, Aryl Hydrocarbon Receptor Interacting Protein Like-1 (AIPL1).- Characterization of Mouse Mutants with Abnormal RPE Cells.- Rod and Cone Pigment Regeneration in RPE65 -/- Mice.- Initial Observations of Key Features of Age-Related Macular Degeneration in APOE Targeted Replacement Mice.- Altered Rhythm of Photoreceptor Outer Segment Phagocytosis in ?5 Integrin Knockout Mice.- Light/Dark Translocation of Alphatransducin in Mouse Photoreceptor Cells Expressing G90D Mutant Opsin.- Slowed Photoresponse Recovery and Age-Related Degeneration in Cones Lacking Gprotein-Coupled Receptor Kinase 1.- Transgenic Animal Studies of Human Retinal Disease Caused by Mutations in Peripherin/RDS.- Transgenic Expression of Leukemia Inhibitory Factor Inhibits Both Rod and Cone Gene Expression.- A Role for bHLH Transcription Factors in Retinal Degeneration and Dysfunction.- Characterisation of a Model for Retinal Neovascularisation.- A Two-Alternative, Forced Choice Method for Assessing Mouse Vision.- Conditional Gene Knockout System in Cone Photoreceptors.- Regulation of Tight Junction Proteins in Cultured Retinal Pigment Epithelial Cells and in VEGF Overexpressing Transgenic Mouse Retinas.- Pathological Heterogeneity of Vasoproliferative Retinopathy in Transgenic Mice Overexpressing Vascular Endothelial Growth Factor in Photoreceptors.- Laser Photocoagulation: Ocular Research and Therapy in Diabetic Retinopathy.- Applying Transgenic Zebrafish Technology to Study the Retina.- Bmi1 Loss Delays Photoreceptor Degeneration in Rd1 Mice.- Transcriptional and Post-Transcriptional Regulation of the Rod cGMP-Phosphodiesterase ?-Subunit Gene.- Gene Therapy and Neuroprotection.- Down-Regulation of Rhodopsin Gene Expression by AAV-Vectored Short Interfering RNA.- Assessing the Efficacy of Gene Therapy in Rpe65 -/- Mice Using Photoentrainment of Circadian Phythm.- Lentiviral Vectors Containing a Retinal Pigment Epithelium Specific Promoter for Leber Congenital Amaurosis Gene Therapy.- Gene Delivery to the Retina Using Lentiviral Vectors.- Potential Use of Cellular Promoter(s) to Target RPE in AAV-Mediated Delivery.- Cytokine-Induced Retinal Degeneration: Role of Suppressors of Cytokine Signaling (SOCS) Proteins in Protection of the Neuroretina.- Disease Mechanisms and Gene Therapy in A Mouse Model for X-Linked Retinoschisis.- Molecular Mechanisms of Neuroprotection in the Eye.- Retinal Damage Caused by Photodynamic Therapy Can Be Reduced Using BDNF.- Controlling Vascular Endothelial Growth Factor: Therapies for Ocular Diseases Associated with Nevascularization.- Intravitreal Injection of Triamcinolone Acetonide for Macular Edema Due to Retinitis Pigmentosa and Other Retinal Diseases.- Cone Survival: Identification of RdCVF.- Neuroprotection of Photoreceptors in the RCS Rat After Implantation of a Subretinal Implant in the Superior or Inferior Retina.- Glutamate Transport Modulation: A Possible Role in Retinal Neuroprotection.- Activation of Cell Survival Signals in the Goldfish Retinal Ganglion Cells after Optic Nerve Injury.- Usher Syndrome.- Roles and Interactions of Usher 1 Proteins in the Outer Retina.- Molecular Analysis of the Supramolecular Usher Protein Complex in the Retina.- Stem Cells, Transplantation and Retinal Repair.- Limited Neural Differentiation of Retinal Pigment Epithelium.- Retinal Pigment Epithelial Cells from Thermally Responsive Polymer-Grafted Surface Reduce Apoptosis.- Retinal Transpilantation.- Microarray Analysis Reveals Retinal Stem Cell Characteristics of the Adult Human Eye.- Using Stem Cells to Repair the Degenerate Retina.- Opic Nerve Regeneration: Molecular Pre-Requisites and the Role of Training.- Retinal Ganglion Cell Remodelling in Experimental Glaucoma.- Induced Retinal Degenerations.- Neural Plasticity Revealed by Light-Induced Photoreceptor Lesions.- Factors Underlying Circadian Dependent Susceptibility to Light Induced Retinal Damage.- Space Flight Environment Induces Degeneration in the Retina of Rat Neonates.- Toxicity of Hyperoxia to the Retina: Evidence from the Mouse.- Treatment with Carbonic Anhydrase Inhibitors Depresses Electroretinogram Responsiveness in Mice.- Injury-Induced Retinal Ganglion Cell Loss in the Neonatal Rat Retina.- Basic Science Underlying Retinal Degeneration.- Arrestin Translocation in Rod Photoreceptors.- Binding of N-Retinylidene-Pe to BACA4 and a Model for its Transport Across Membranes.- The Chaperone Function of the LCA Protein AIPL1.- CRALBP Ligand and Protein Interactions.- Functional Study of Photoreceptor PDE?.- Localization of the Insulin Receptor and Phosphoinositide 3-Kinase in Detergent-Resistant Membrane Rafts of Rod Photoreceptor Outer Segments.- Mertk Activation During RPE Phagocytosis in Vivo Requires ?V?5 Integrin.- Photoreceptor Retinol Dehydrogenases.- Pigment Epithelium-Derived Growth Factor Inhibits Fetal Bovine Serum Stimulated Vascular Endothelial Growth Factor Synthesis in Cultured Human Retinal Pigment Epithelial Cells.- The Retinal Pigment Epithelium Apical Microvilli and Retinal Function.- Upregulation of Transglutaminase in the Goldfish Retina During Optic Nerve Regeneration.- Survival Signaling in Retinal Pigment Epithelial Cells in Response to Oxidative Stress: Significance in Retinal Degenerations.