The Myc Gene

The Myc world within Reach.- Methods for the Expression, Purification, Preparation and Biophysical Characterization of Constructs of the c-Myc and Max b-HLH-LZs.- Analyzing Myc in Cell Transformation and Evolution.- Identifying Myc Interactors.- Detection of c-Myc Protein-Protein Interactions And Phosphorylation Status by Immunoprecipitation.- An Efficient Way of Studying Protein–Protein Interactions Involving HIF-α, c-Myc, and Sp1.- Methods for Determining Myc-induced Apoptosis.- Methods to Study Myc-regulated Cellular Senescence.- Chromatin Immunoprecipitation Assays for Myc and N-Myc.- Methods to Quantify microRNAs in the Myc Gene Network for Posttranscriptional Gene Repression.- Genome-wide Analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA-binding by Next Generation Sequencing.- A High Throughput siRNA Screening Platform to Identify MYC Synthetic Lethal Genes as Candidate Therapeutic Targets.- Investigating Myc-dependent Translational Regulation in Normal and Cancer Cells.- Studying Myc’s Role in Metabolism Regulation.- Generation of a Tetracycline Regulated Mouse Model of MYC-induced T-cell Acute Lymphoblastic Leukemia.- Methods to Assess Myc Function in Intestinal Homeostasis, Regeneration and Tumourigenesis.- Detection of c-myc Amplification in Formalin-fixed Paraffin-Embedded Tumor Tissue by Chromogenic in situ Hybridization (CIHS).- Cell-Based Methods for the Identification of MYC-Inhibitory Small Molecules.