Hemostasis and Thrombosis

Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders.- Preanalytical Issues in Hemostasis and Thrombosis Testing.- The Interface between Immunotransfusion and Hemostasis and Thrombosis Testing.- Optimizing the Verification of Mean Normal Prothrombin Time (MNPT) and International Sensitivity Index (ISI) for Accurate Conversion of Prothrombin Time (PT) to International Normalized Ratio (INR).- Performance of Activated Partial Thromboplastin Time (APTT): Determining Reagent Sensitivity to Factor Deficiencies, Heparin, and Lupus Anticoagulants.- Performance and Interpretation of Mixing Tests in Coagulation.- D-Dimer Testing: Laboratory Aspects and Current Issues.- Determination of Fibrinogen and Thrombin Time (TT).- An Overview of Thrombophilia and Associated Laboratory Testing.- Laboratory Testing for Activated Protein C Resistance (APCR).- Assessment of Hereditary Thrombophilia: Performance of Protein C (PC) Testing.- Assessment of Hereditary Thrombophilia: Performance of Protein S (PS) Testing.- Assessment of Hereditary Thrombophilia: Performance of Antithrombin (AT) Testing.- Lupus Anticoagulant Testing: Diluted Russell Viper Venom Time (dRVVT).- Lupus Anticoagulant Testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT).- Solid Phase Immunoassay for the Detection of Anticardiolipin Antibodies.- Solid Phase Immunoassay for the Detection of Anti-β2 Glycoprotein I Antibodies.- Measuring Direct Oral Anticoagulants.- Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing.- One-Stage Factor VIII Assays.- Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A.- Assessment of Factor XIII.- Detection and Measurement of Factor Inhibitors.- Platelet Function Tests: Preanalytical Variables, Clinical Utility, Advantages and Disadvantages.- Platelet Function Analyzed by Light Transmission Aggregometry.- Whole Blood Platelet Aggregometry.- Assessment of Platelet Function in Whole Blood by Flow Cytometry.- Flow Cytometry Protocols for Assessment of Platelet Function in Whole Blood.- Diagnosis or Exclusion of Von Willebrand Disease Using Laboratory Testing.- Laboratory Testing for Von Willebrand Factor Antigen (VWF:Ag).- Laboratory Testing for Von Willebrand Factor Collagen Binding (VWF:CB).- Laboratory Testing for Von Willebrand Factor Ristocetin Cofactor (VWF:RCo).- Laboratory Testing for Von Willebrand Factor Activity by Glycoprotein Ib Binding Assays (VWF:GPIb).- Laboratory Testing for Von Willebrand Factor Factor VIII Binding (for 2N VWD).- Ristocetin-Induced Platelet Aggregation (RIPA) and RIPA Mixing Studies.- Laboratory Testing for Von Willebrand Factor Multimers.- Thrombin Generation Assays (TGA).- The Overall Haemostatic Potential (OHP) Assay.- Thromboelastography (TEG).- Post-Analytical Issues in Hemostasis and Thrombosis Testing.<p></p>