Benjamin D. Cowley, Jr.,
John J. Bissler
Polycystic Kidney Disease
Translating Mechanisms into Therapy
Gebonden Engels 2018 9781493977826
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.
Specificaties
ISBN13:9781493977826
Taal:Engels
Bindwijze:gebonden
Uitgever:Springer New York
Lezersrecensies
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Inhoudsopgave
PART 1. POLYCYSTIC KIDNEY DISEASE GENES & PROTEINS.- 1. Classical Polycystic Kidney Disease (PKD): Gene Structures and Mutations and Protein Structures and Functions.- 2. Bardet-Biedl Syndrome.- 3. Cystic Kidney Diseases Associated with Increased Cancer Risk: Tuberous Sclerosis Complex, Von Hippel Lindau, and Birt Hogg Dubé.- PART 2. POLYCYCSTIC KIDNEY DISEASE: MECHANISMS OF DISEASE.- 4. Aberrant Cellular Pathways in PKD.- 5. Cilia and Polycystic Kidney Disease.- 6. The Role of Inflammation and Fibrosis in Cystic Kidney Disease.- PART 3. CLINICAL FEATURES.- 7. Imaging-based Diagnosis of Autosomal Dominant Polycystic Kidney Disease.- 8. Renal Structural Involvement in Autosomal Dominant Polycystic Kidney Disease: Cyst Growth and Total Kidney Volume: Lessons from the Consortium for Radiologic Imaging of Polycystic Kidney Disease (CRISP).- 9. Renal Complications: Pain, Infection and Nephrolithiasis.- 10. ADPKD Extrarenal Manifestations: Polycystic Liver Disease.- 11. Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease.- PART 4. CLINICAL TRIALS AND EMERGING THERAPIES.- 12. Role of Renin- Angiotensin- Aldosterone System Inhibition in Autosomal Dominant Polycystic Kidney Disease.- 13. Vasopressin Receptor Antagonism.- 14. End-stage Renal Disease in Patients with Autosomal Dominant Polycystic Kidney Disease.- 15. Polycystic Kidney Disease: Translating Mechanisms into Therapy Management of ADPKD Today.<p></p>
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