Alpha-Synuclein

<div>Assays for Neuronal Defects Caused by Early Formation of α-Synuclein Inclusions in Primary Cultured Neurons.-&nbsp;Immunohistochemical Detection of Alpha-Synuclein in Unfixed Human Brain Tissue.-&nbsp;Kinetic Measurements of Endocytosis and Exocytosis in Cultured Neurons.-&nbsp;Detection of Misfolded α-Synuclein Aggregates in Cerebrospinal Fluid by the Protein Misfolding Cyclic Amplification Platform.-&nbsp;Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain using Pre-Formed Fibrils.-&nbsp;Quantification of Alpha-Synuclein in Biological Fluids by Electrochemiluminescence-Based Detection.-&nbsp;Alpha-Synuclein Proximity Ligation Assay (AS-PLA) in Brain Sections to Probe for Alpha-Synuclein Oligomers.-&nbsp;Studying α-Synuclein Conformation by Intact-Cell Crosslinking.-&nbsp;C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques.-&nbsp;Recombinant Expression and Purification of N-Acetylated Alpha-Synuclein.-&nbsp;CircularDichroism and Isothermal Titration Calorimetry to Study the Interaction of α-Synuclein with Membranes.-&nbsp;Yeast-Based Screens to Target Alpha-Synuclein Toxicity.-&nbsp;Probing Structural Changes in Alpha Synuclein by Nuclear Magnetic Resonance Spectroscopy.-&nbsp;Measuring Mitochondrial Dysfunction Caused by Soluble α-Synuclein Oligomers.-&nbsp;Monitoring α-Synuclein Proteotoxicity in Drosophila Models.-&nbsp;Detection of α-Synuclein in Biological Samples using Mass Spectrometry.-&nbsp;Single-Molecule FRET Detection of Early-Stage Conformations in&nbsp;α-Synuclein Aggregation.-&nbsp;In Situ Peroxidase Labelling and Mass-Spectrometry of Alpha-Synuclein in Rat Cortical Neurons.-&nbsp;Probing Alpha-Synuclein Conformations by Electron Paramagnetic Resonance (EPR) Spectroscopy.-&nbsp;Expression and Purification of Untagged&nbsp;α-Synuclein.-&nbsp;Generation and Analysis of Viral Vector Mediated Rodent Models for Parkinson’s Disease.</div>