Shayne C. Gad
In Vitro Toxicology
Gebonden Engels 2000 2e druk 9781560327691Levertijd ± 11 werkdagen
Gratis verzonden
Samenvatting
Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity.
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Inhoudsopgave
Contributors; Preface 1. Introduction 2. General Principles for In Vitro 3. Ocular Toxicity Assessment In Vitro Toxicology 4. In Vitro Methods to Predict Skin Irritation 5. Lethality Testing 6. In Vitro Genetic Toxicity Testing 7. Pyrogenicity and Muscle Irritation 8. In Vitro Models for Evaluating Developmental Toxicity 9. Neurotoxicology In Vitro 10. In Vitro Assessment of Nephrotoxicity 11. Primary Hepatocyte Culture as an In Vitro Toxicologic System for the Liver 12. Application of In Vitro Model Systems to Study Cardiovascular Toxicity 13. Gastrointestinal Toxicology: In Vitro Test Systems 14. In Vitro Immonotoxicology 15. Strategy and Tactics for Employment 16. Scientific and Regulatory Considerations in the Development of In Vitro Techniques in Toxicology 17. Safety Issues in the Use of Human Tissue by In Vitro Metabolism and Toxicology Laboratories; Index
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