Natural Products
Drug Discovery and Therapeutic Medicine
Gebonden Engels 2005 2005e druk 9781588293831Samenvatting
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Specificaties
Lezersrecensies
Inhoudsopgave
Natural Products and Drug Discovery
Arnold L. Demain and Lixin Zhang
Part II. Strategies
Integrated Approaches for Discovering Novel Drugs From Microbial Natural Products
Lixin Zhang
Automated Analyses of HPLC Profiles of Microbial Extracts: A New Tool for Drug Discovery Screening
José R. Tormo and Juan B. García
Manipulating Microbial Metabolites for Drug Discovery and Production
C. Richard Hutchinson
Improving Drug Discovery From Microorganisms
Chris M. Farnet and Emmanuel Zazopoulos
Developments in Strain Improvement Technology: Evolutionary Engineering of Industrial Microorganisms Through Gene, Pathway, and Genome Shuffling
Stephen B. del Cardayré
Part III. Specific Groups of Drugs
The Discovery of Anticancer Drugs From Natural Sources
David J. Newman and Gordon M. Cragg
Case Studies in Natural-Product Optimization: Novel Antitumor Agents Derived From Taxus brevifolia and Catharanthus roseus
Jian Hong and Shu-Hui Chen
Terpenoids As Therapeutic Drugs and Pharmaceutical Agents
Guangyi Wang, Weiping Tang, and Robert R. Bidigare
Challenges and Opportunities in the Chinese Herbal Drug Industry
Wei Jia and Lixin Zhang
Arsenic Trioxide and Leukemia: From Bedside to Bench
Guo-Qiang Chen, Qiong Wang, Hua Yan, and Zhu Chen
Part IV. Microbial Diversity
New Methods to Access Microbial Diversity for Small Molecule Discovery
Karsten Zengler, Ashish Paradkar, and Martin Keller
Accessing the Genomes of Uncultivated Microbes for Novel Natural Products
Asuncion Martinez, Joern Hopke, Ian A. MacNeil, and Marcia S. Osburne
Part V. Specific Sources
New Natural-Product Diversity From Marine Actinomycetes
Paul R. Jensen and WilliamFenical
Novel Natural Products From Rainforest Endophytes
Gary Strobel, Bryn Daisy, and Uvidelio Castillo
Biological, Economic, Ecological, and Legal Aspects of Harvesting Traditional Medicine in Ecuador
Alexandra Guevara-Aguirre and Ximena Chiriboga
Index
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