Chronic Lymphocytic Leukemia

I. Introduction.- 1 The Natural History of CLL: Historical Perspective.- II. Biology and Genetics.- 2 Genetics of B-Cell Chronic Lymphocytic Leukemia.- 3 Molecular Biology of Chronic Lymphocytic Leukemia.- 4 The Heterogeneous Origin of the B-CLL Cell.- 5 Pathogenesis of Impaired Cellular Immune Function in CLL.- 6 Cytokines and Soluble Molecules in CLL.- III. Clinical Aspects: Diagnosis.- 1 Immunophenotypic Differential Diagnosis and Cell Cycle Analysis.- 8 Common Cytogenetic Abnormalities.- 9 Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia.- IV. Clinical Aspects: Prognosis.- 10 Staging of Chronic Lymphocytic Leukemia.- 11 Prognostic Indicators of Chronic Lymphocytic Leukemia.- V. Clinical Aspects: Treatment.- 12 Guidelines for Clinical Management of CLL.- 13 Chemotherapy of Chronic Lymphocytic Leukemia.- 14 Autologous and Allogeneic Transplantations for Chronic Lymphocytic Leukemia.- 15 Monoclonal Antibody Therapy in Chronic Lymphocytic Leukemia.- 16 Immunotoxin Therapy of Chronic Lymphocytic Leukemia.- 17 New Treatment Strategies in Chronic Lymphocytic Leukemia.- 18 Gene Therapy of Chronic Lymphocytic Leukemia.- VI. Clinical Aspects: Complications.- 19 Infections in Patients With Chronic Lymphocytic Leukemia.- 20 Autoimmune and Hypersplenic Cytopenias.- 21 Clonal Evolution and Second Malignancies in B-CLL.- VII. Familial and Juvenile Chronic Lymphocytic Leukemia.- 22 Inherited Predisposition to Chronic Lymphocytic Leukemia.- 23 Young Patients With Chronic Lymphocytic Leukemia.