Proprotein Convertases

<p>Part I: Reminiscences</p><p> </p><p>1. On the Discovery of Precursor Processing</p><p>            Donald F. Steiner</p><p> </p><p>2. The Prohormone Theory and the Proprotein Convertases: It Is All About Serendipity</p><p>            Michel Chrétien</p><p> </p><p>Part II: Biochemistry and Cell Biology</p><p> </p><p>3. The Proprotein Convertases, 20 Years Later</p><p>            Nabil G. Seidah</p><p> </p><p>4. Insights from Bacterial Subtilases into the Mechanisms of Intramolecular Chaperone-Mediated Activation of Furin</p><p>            Ujwal Shinde and Gary Thomas</p><p> </p><p>5. The Novel Role of Cathepsin L for Neuropeptide Production Illustrated by Research Strategies in Chemical Biology with Protease Gene Knockout and Expression</p><p>            Lydiane Funkelstein and Vivian Hook</p><p> </p><p>6. In Vitro Assay for Protease Activity of Proprotein Convertase Subtilisin Kexins (PCSKs): An Overall Review of Existing and New Methodologies</p><p>            Ajoy Basak, Andrew Chen, Swapan Majumdar, and Heather Palmer Smith</p><p> </p><p>7. Inhibitor Screening of Proprotein Convertases Using Positional Scanning Libraries</p><p>            Iris Lindberg and Jon R. Appel</p><p> </p><p>8. Analyses of PCSK9 Post-Translational Modifications Using Time-of-Flight Mass Spectrometry</p><p>            Thilina Dewpura and Janice Mayne</p><p> </p><p>Part III: Molecular Biology and Genetics</p><p> </p><p>9. The Molecular Biology of Furin-Like Proprotein Convertases in Vascular Remodelling</p><p>            Philipp Stawowy and Kai Kappert</p><p> </p><p>10. Identification of the Myosin Heavy Polypeptide 9 as a Downstream Effector of the Proprotein Convertases in the Human Colon Carcinoma HT-29 Cells</p><p>            Nathalie Scamuffa, Fabien Calvo, and Abdel-Majid Khatib</p><p> </p><p>11. Regulation of 7B2 mRNA Translation: Dissecting the Role of Its 5’-Untranslated Region</p><p>            Haidy Tadros, Gunther Schmidt, Francine Sirois, and Majambu Mbikay</p><p> </p><p>12. Analysis of Epigenetic Alterations to Proprotein Convertase Genes in Disease</p><p>            YangXin Fu and Mark W. Nachtigal</p><p> </p><p>13. Genetic and Functional Characterization of PCSK1</p><p>            Hélène Choquet, Pieter Stijnen, and John W.M. Creemers</p><p> </p><p>Part IV: Experimental Models</p><p> </p><p>14. Prohormone Processing in Zebrafish</p><p>            Michael G. Morash, Kelly Soanes, and Younes Anini</p><p> </p><p>15. Use of Zebrafish and Knockdown Technology to Define Proprotein Convertase Activity</p><p>            Babykumari P. Chitramuthu and Hugh P.J. Bennett</p><p> </p><p>16. Characterization of Impaired Processing of Neuropeptides in the Brains of Endoproteases Knockout Mice</p><p>            Margery C. Beinfeld</p><p> </p><p>17. Quantitative Peptidomics of Mice Lacking Peptide-Processing Enzymes</p><p>            Jonathan Wardman and Lloyd D. Fricker</p><p> </p><p>18. A Proteomic Protocol to Identify Physiological Substrates of Proprotein Convertases</p><p>            Guiying Nie and Andrew N. Stephens</p><p> </p><p>19. Neurophenotyping Genetically-Modified Mice for Social Behavior</p><p>            Ramona M. Rodriguiz, Jennifer S. Colvin, and William C. Wetsel</p>