Clinical Research Informatics

Section I: Contexts of Clinical Research Informatics.- Introduction to Clinical Research Informatics.- From Notations to Data: The Digital Transformation of Clinical Research.- Clinical Research Environment. - Statistical and Study Design Foundations of Clinical Research.- Informatics Approaches to Participant Recruitment.- The Evolving Role of Consumers.- Clinical Research in the Post-Genomic Era.- Section II: Data Management and Systems in Clinical Research.- Clinical Research Information Systems.- Study Protocol Representation.- Data Quality in Clinical Research.- Patient-Reported Outcome Data.- Biobanking Challenges and Informatics Opportunities.- Patient Registries.- Section III: Knowledge Representation and Discovery.- Knowledge Representation and Ontologies.- Non-hypothesis Driven Research: Data Mining and Knowledge Discovery.- Natural Language Processing, Electronic Health Records, and Clinical Research.- Section IV: The Future of Clinical Research, Health, and Clinical Research Informatics.- Data Sharing: Electronic Health Records and Research Interoperability.- Standards Development and the Future of Research Data Sources, Interoperability, and Exchange.- Pharmacovigilance.- Clinical Trials Registries and Results Databases.- Future Directions in Clinical Research Informatics.- Index.