Meer over Ashim K Mitra

Ashim K Mitra

Ocular Transporters and Receptors

Name: Ocular Transporters and Receptors
Author: Ashim K Mitra

Their Role in Drug Delivery

Gebonden Engels 2013 9781907568862

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Samenvatting

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.

Specificaties

ISBN13:9781907568862

Taal:Engels

Bindwijze:Gebonden

Uitgever:Elsevier Science

Serie:Woodhead Publishing Series in Biomedicine

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Inhoudsopgave

List of figures and tables About the authors Chapter 1: Eye: anatomy, physiology and barriers to drug delivery Abstract: 1.1 Introduction 1.2 Anatomy and physiology of the eye 1.3 Barriers to ocular drug delivery 1.4 Conclusions 1.5 Acknowledgements Chapter 2: Biology of ocular transporters: efflux and influx transporters in the eye Abstract: 2.1 Introduction 2.2 SLC transporters 2.3 ABC transporters 2.4 Conclusions Chapter 3: Characterization of ocular transporters Abstract: 3.1 Introduction 3.2 Molecular and cellular characterization 3.3 Functional characterization of transporters Chapter 4: Transporters and receptors in the anterior segment of the eye Abstract: 4.1 Introduction 4.2 Transporters and receptors 4.3 Anterior chamber influx transporters 4.4 Anterior chamber efflux transporters 4.5 Anterior chamber receptors 4.6 Other miscellaneous anterior chamber receptors 4.7 Conclusions Chapter 5: Transporters and receptors in the posterior segment of the eye Abstract: 5.1 Introduction 5.2 Influx transporters in posterior segment of the eye 5.3 Receptors in posterior segment of the eye 5.4 ABC transporters 5.5 Conclusion Chapter 6: Transporters in drug discovery and delivery: a new paradigm in ocular drug design Abstract: 6.1 Introduction 6.2 Transporter-targeted drug delivery to the anterior segment 6.3 Transporter-targeted drug delivery to the posterior segment 6.4 Conclusion Chapter 7: Transporter-metabolism interplay in the eye Abstract: 7.1 Introduction 7.2 Metabolizing enzymes in ocular tissues 7.3 Impact of disease state on the expression of metabolizing enzymes 7.4 Efflux transporters and metabolism interplay 7.5 Potential impact of the efflux metabolism interplay in ocular bioavailability 7.6 Drug design and formulation strategies to overcome the efflux and metabolism interplay 7.7 Conclusion Index

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