Proteostasis and Disease
From Basic Mechanisms to Clinics
Paperback Engels 2021 9783030382681Samenvatting
This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology.
Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Specificaties
Lezersrecensies
Inhoudsopgave
1. Ubiquitin-regulated cell proliferation and cancer -Beatriz Pérez-Benavente, Alihamze Fathinajafabadi Nasresfahani and Rosa Farràs
2. Ubiquitin, SUMO and NEDD8 as therapeutic targets in cancer -Pierre Gâtel, Marc Piechaczyk and Guillaume Bossis
3.The proteasome system in health and disease - Olivier Coux, Barbara Zieba and Silke Meiners
4. Proteostasis dysregulation in pancreatic cancer- Leena Arpalahti, Caj Haglund, and Carina I. Holmberg
5. Divergent modulation of proteostasis in prostate cancer- Petek Ballar Kirmizibayrak, Burcu Erbaykent Tepedelen, Oguz Gozen, Yalcin Erzurumlu
6. Resistance to the proteasome inhibitors: lessons from multiple myeloma and mantle cell lymphoma - Maria Gonzalez-Santamarta, Grégoire Quinet, Diana Reyes-Garau, Brigitte Sola, Gaël Roué and Manuel S. Rodriguez
PART II Neurodegeneration7. Altered proteostasis in neurodegenerative tauopathies - Katerina Papanikolopoulou and Efthimios MC Skoulakis
8. The ubiquitin system in Alzheimer’s Disease - Lee D. Harris, Sarah Jasem & Julien D. F. Licchesi
9. The interplay between proteostasis systems and Parkinson's disease - Diana F. Lázaro and Tiago F. Outeiro
10. Machado-Jospeh Disease: A stress combating deubiquitylating enzyme changing sides - Nico P. Dantuma and Laura K. Herzog
PART III Infection, inflammation and developmental disorders11. SUMO and cytoplasmic RNA viruses: from enemies to best friends - Ahmed El Motiam, Santiago Vidal, Rocío Seoane, Yanis H Bouzahe, José González-Santamaría, Carmen Rivas
12. The role of proteostasis in the regulation of cardiac intercellular communication - Daniela Batista-Almeida, Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Henrique Girao
13. By the tips of your cilia: ciliogenesis in the retina and the ubiquitin-proteasome system - Vasileios Toulis, Gemma Marfany
14. TRIM E3 ubiquitin ligases in rare genetic disorders - Germana Meroni
PART IV Diet
15. We are what we eat: Ubiquitin-proteasome System (UPS) modulation through dietary products -Eleni Panagiotidou and Niki Chondrogianni
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