Liver Elastography

<p>Measurement of Liver stiffness – History, techniques, performance .- Transient elastography.- Sampling error.- ARFI and other US-based techniques .- MRE.- Animal studies.- Take home message.- Liver stiffness and its association with fibrosis&nbsp; .- Fibrosis Histology.- Disease etiology.- Take home message.- Important clinical confounders of LS .- CVP heart failure.- Arterial pressure .- Portal pressure.- Cholestasis.- Hydrostatic pressure.- Outflow inflow concept.- Nutrition and alcohol consumption.- position.- Histology correlates&nbsp;&nbsp;&nbsp;&nbsp; ballooning steatosis inflammation.- Genes Rausch.- Else amyloidosis, mastocytosis.- Take home message.- LS and important clinical endpoints.- HCC.- Portal hypertension, bleeding.- Survival.- Disease specific aspects.- LTX.- Hepatic decompensation.- Take home message.- &nbsp;How to use LS in clinical practice: State of the art 2019 .- Standard procedure&nbsp; position, technique, fasting.- Dissection from inflammation: Intervention and inflammation-adapted.- Disease specific algorithms: portal vs lobular vs cholestatic disease.- LS in combinations with spleen stiffness: portal hypertension and bleeding.- Spleen stiffness, techniques, spleen size.- Localization of hepatic disease: lobular, portal versus extrahepatic.- Comparison of various techniques .- Screening of populations .- Combination with serum markers.- Sparing of biopsies.- Take home message.- Future applications of LS.- Cardiololgy cardiac cirrhosis.- Intensive care unit&nbsp; mortality CVP.- Nephrology water retention.- Hematology.- LTX setting waiting list.- Screening in addiction medicine.- Pregnancy.- Therapeutic monitoring of portal pressure lowering drugs.- Other organs.- Specific interpretation in clinical context.- LS and hepatic vs non-hepatic ascites Ascites.- LS changes in cirrhotics.- Mechanic cholestasis.- Clinical cases.- CAP.- Steatosis techniques.- CAP performance.- Genetics .- Molecular insights based on LS.- Pressure hypothesis of liver fibrosis.- Stiffness in vitro.- Extracellular matrix and stiffness Matrix .- Future directions and open questions.- Molecular basics of LS.- Directions of future studies.- Future diagnostic algorithms.</p><p></p>