Frontotemporal Dementias
Emerging Milestones of the 21st Century
Paperback Engels 2022 9783030511425Samenvatting
Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind.
In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders.
This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD.
The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD.
This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD.
Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.
Specificaties
Lezersrecensies
Inhoudsopgave
Table of Contents
1. Behavioural variant FTD: recent advances in the diagnosis and understanding of the disorder
John Hodges, Olivier Piguet, Rebekah Ahmen
2. The neuropsychiatry of frontotemporal dementia
Bruce Miller
3. Nosology and Neuropathology of Language in Primary Progressive Aphasia
Marsel Mesulam, S. Weintraub, E. Rogalski, E. Bigio
4. Measuring Behavior and Cognition in FTLD
Kate Rankin et al
5. Clinical update on C9orf72: FTD, ALS and beyond
Isabelle Le Ber and Brad Boeve
6. Clinical aspects of familial FTLD associated with MAPT and GRN mutations
Brad Boeve and Howie Rosen
7. Neuroimaging in Frontotemporal Lobar Degeneration
Sheena Dev, Bradford C. Dickerson, Alexandra Touroutoglou
8. The FTD Prevention Initiative - linking together genetic FTD cohort studies
Jonathan Rohrer and Adam Boxer
9. Fluid Biomarkers of Frontotemporal Lobar Degeneration
John van Swieten and Emma van der Ende
10. Cross-cultural perspectives on frontotemporal degeneration
Chiadi U. Onyike et al
11. Clinical characteristics and Neuropathology of PSP, CBD and Related 4R-Tauopathies
Dennis Dickson, Irene Litvan, D.Coughlin, Keith A. Josephs
12. Tau protein and frontotemporal dementias
Michel Goedert, Maria G Spillantini
13. FTLD-TDP pathological subtypes: clinical and mechanistic significance
Manuela Neumann, Edward Lee, Ian Mackenzie
14. Lysosomal dysfunction as a pathogenic mechanism in FTD: Evidence from PGRN and TMEM106B genetics and biology
Xiaolai Zhou, Thomas Kukar, Rosa Rademakers
15. Future trends in understanding the pathological role of TDP-43 and FUS proteins
Emanuele Buratti
16. Description of a new data resource for FTD including multiomic data on human post mortem brain (MAPT, GRN, C9orf72), matching mouse models and iPS models
Peter Heutink and Kevin Menden
17. Mendelian and sporadic FTD: avenues from genetics to disease pathways through in-silico prediction and modeling
Raffaele Ferrari
18. FTLD treatment: Current Practice and Future Possibilities
Adam Boxer and Peter Ljubenkov
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