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Mathematical, Computational and Experimental T Cell Immunology

Gebonden Engels 2021 9783030572037
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

Mathematical, statistical, and computational methods enable multi-disciplinary approaches that catalyse discovery. Together with experimental methods, they identify key hypotheses, define measurable observables and reconcile disparate results. This volume collects a representative sample of studies in T cell immunology that illustrate the benefits of modelling-experimental collaborations and which have proven valuable or even ground-breaking. Studies include thymic selection, T cell repertoire diversity, T cell homeostasis in health and disease, T cell-mediated immune responses, T cell memory, T cell signalling and analysis of flow cytometry data sets. Contributing authors are leading scientists in the area of experimental, computational, and mathematical immunology. Each chapter includes state-of-the-art and pedagogical content, making this book accessible to readers with limited experience in T cell immunology and/or mathematical and computational modelling.

Specificaties

ISBN13:9783030572037
Taal:Engels
Bindwijze:gebonden
Uitgever:Springer International Publishing

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Inhoudsopgave

<p>Cytokine receptor signaling and CD4/CD8 lineage choice&nbsp;during T cell development in the thymus.-&nbsp;An agent-based model of T helper cell fate decisions in the thymus.-&nbsp;Modelling naive T cell homeostasis.-&nbsp;Mechanistic models of CD4 T cell homeostasis&nbsp;and reconstitution in health and disease.-&nbsp;Section 1MODELING&nbsp;THE DYNAMICS OF CD4+ T CELLS IN HIV-&nbsp;1 INFECTION.-&nbsp;Modelling the response to Interleukin-7 therapy&nbsp;in HIV-infected patients.-&nbsp;Modeling immunopathology during persistent viral infections.-&nbsp;Delay in differentiation may suggest division of&nbsp;labour in models for CD8+ T cell differentiation.-&nbsp;Inferring differentiation order in adaptive&nbsp;immune responses from population level data.-&nbsp;Experimental and mathematical approaches to quantify&nbsp;recirculation kinetics of lymphocytes.-&nbsp;The public face and private lives of T cell receptor repertoires.-&nbsp;Population dynamics of immune repertoires.-&nbsp;Mathematical Modelling of T cell activation.-&nbsp;Agent-based model of heterogeneous T cell activation in vitro.-&nbsp;CTLA-4 mediated ligand trans-endocytosis: a stochastic model.-&nbsp;Automated gating and dimension reduction of&nbsp;high-dimensional cytometry data.- Index.<br></p>

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        Mathematical, Computational and Experimental T Cell Immunology