Early Osteoarthritis

<p>I Definition and Epidemiology.- 1 Definition of&nbsp; “early Osteoarthritis” .- 2 Early signs of OA in x-rays.- 3 MRI measures of early OA – the ACL-OA score.- 4 Relaxometrie as early measure of OA.- 5 Epidemiology of Osteoarthritis and the importance of early onset-Katz (or delegate).- 6 Economic aspects of early OA.- 7 Frequency, Epidemiology and Cost of ACL injuries.- 8 The human ACL injury model of early OA.- 9 The risk of early OA after joint fracture.- 10 The clinical manifestation of early OA.- II Basic science aspects of the disease process.- 11 Biomechanics of instability and its relationship to OA.- 12 Fluid dynamics and rheology in the arthritic joint.- 13 How does articular cartilage actually break down?.- 14 Early OA after tibial plateau fracture in the rat.- 15 Matrix degradation after injury.- 16 Collagen breakdown in hip and knee joint over time.- 17 Inflammation after ACL injury.- 18 The role of the “Inflammatype”.- 19 Immune response and early OA.- 20Macrophages in early OA.- 21 Vesicles and MSC’s.- III Clinical Treatment of early OA (non-op).- 22 Early clinical manifestations of early OA.- 23 When is a chondral defect relevant?.- 24 Role of cortisone in the treatment of early OA.- 25 Viscosupplementation in early OA.- 26 The role of PRP in early OA.- 27 What is the current role and promise of stem cell therapy in early OA.- 28 Role of iPS cells for OA?.- 29 Fat derived stem cells.- 30 BMAC.- IV Clinical Treatment of early OA (operative).- 30 The role of alignment in the treatment of early OA.- 31 Meniscus injury and early OA, when to operate, when to repair, when to resect?.- 32 Role of arthroscopic debridement, microfracture or washouts.- 33 Osteochondral allograft for early OA.- 34 Cell based procedures for early OA.- 35 Chondral defect repair using a coral based implant.- 36 Options for Early Osteoarthritis treatment in the Shoulder.</p>