Infection in Knee Replacement

Epidemiology and socioeconomic impact of infections in knee replacement .- Aetiology and pathogenesis of knee replacement infections.Biomaterials in artificial joint replacement. The role of the surface on bacteria-implant interactions.- In-vitro and in-vivo models for the study of prosthetic joint infections. Clinical manifestation. General and local symptoms. Diagnosis. Laboratory diagnosis .- Microbiological diagnosis.- Molecular analysis and histological evaluation.- Imaging.- Definitional criteria and algorithms of diagnosis. Treatment of knee replacement infections. Systemic antibiotic therapy.- Innovative pharmacological strategies.- Surgical approaches.- DAIR  .- One stage.- Two stage.- Static spacers.- Dynamic spacers.- Arthrodesis.- Outcomes.- Complications.- Resistant germs. Current evidence on prevention of knee replacement infections. Medical optimization of patient prior to surgery.- Antibiotic prophylaxis during primary and revision joint replacement.- Preoperative management.- Intraoperative management.- Dental Procedures after joint replacement.- Thromboprophylaxis and haematomas.- Antibiotic impregnated cement.- Arthroplasty following Prior septic arthritis.- Antibiotic-loaded cement in primary and revision joint replacement.- Operative Room.- Tourniquet.- Intraarticular injection prior Joint replacement.