Andreas Brunschweiger,
Damian W. Young
DNA-Encoded Libraries
Gebonden Engels 2022 9783031186288Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
This book deals with the recent advances in DNA-Encoded Library (DEL) technology that has emerged as an alternative to high throughput screening (HTS) over the last decade and has been heralded as a "disruptive" technology for drug discovery.
The book aims to provide a comprehensive overview of all of the major components of the DEL process from conception to bench execution and clinical investigations. The contributions from experts in the field combine different perspectives from academia and industry. The book will be of interest to researchers in the drug discovery field as well as to graduate students and scholars who are interested in this rapidly improving technology.
Specificaties
ISBN13:9783031186288
Taal:Engels
Bindwijze:gebonden
Uitgever:Springer International Publishing
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Inhoudsopgave
<div>A History of Selection-Based High-Throughput Screening Technologies for Hit Identification.- Barcoding Strategies for the Synthesis of Genetically Encoded Chemical<br>Libraries.- Advancements in DEL-Compatible Chemical Reactions.- Design Considerations in Constructing and Screening DNA-Encoded Libraries.- Cheminformatics Approaches Aiding the Design and Selection of DNA-Encoded Libraries.- Selection Strategies in DNA-Encoded Libraries.- From DEL Selections to Validated Hits to Clinical Leads.- A Perspective on 30 Years of DNA-Encoded Chemistry.</div><div><br></div><div><br></div><div><br></div><p> </p><div><br></div>
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