Frailty

Part 1 - Frailty and Related Concepts – An Overview (THEOU).- Phenotype.- Deficit accumulation.- Prevalence, incidence and risk factors of frailty.- Integration – A unified frailty framework.- Intrinsic Capacity.- Transitions, Trajectories, and Reversibility.- Sarcopenia and Frailty: a common thread across multiple comorbidities.- Complications of Frailty.- Sex Differences and Frailty.- Part 2 - Mechanisms – Pathogenesis & Research.- Inflammaging & Immunosenescence.- Implications of the Exposome for Frailty.- Preclinical Models Of Frailty.- Biomarkers of frailty.- Mitochondrial alterations and signaling in aging, frailty, and sarcopenia: an integrated view.- Human Microbiome and Frailty: From Observations of Clinically Relevant Associations to Insights into Biological Mechanisms.- Part 3 - Assessment (THEOU).- Clinical Frailty Scale.- Frailty Measure Development, Selection and Implications.- Pictorial Fit-Frail Scale.- Frailty Assessment: The FRAIL scale.- Edmonton Frail Scale.- The Tilburg Frailty Indicator (TFI).- The Study of Osteoporotic Fractures (SOF) Frailty Index.- Physical Assessments Instruments.- Technology-Based Assessments of Frailty.- Frailty Tools Using Health Care Database.- Part 4 - Management - Treatment and Prevention.- Comprehensive Geriatric Assessment CGA.- Exercise Strategies for Improving Health Outcomes in Older Adults with Comorbidities: The Role of Vivifrail Tailored-Multicomponent Training.- Nutritional Aspects Of Frailty In Older Adults: Undernutrition, Nutrients Consumption, And Diet Patterns.- Deprescribing.- Geroscience-based Interventions.- Integrated Care for Frailty.- Part 5 - Settings of Care.- Frailty in primary care: interventions and opportunities.- Frailty in Acute Care Settings.- Frailty in Nursing Homes.- Rehabilitation.- Palliative care.- Frailty in Home Care.- A community model for detecting and managing frailty.- Part 6 - Other Conditions.- Bidirectional Relationships between COVID-19 and Frailty in Older Adults.- Frailty and Cancer.- Frailty & Cardiovascular Disease.- Frailty in older people with diabetes mellitus.- Frailty and Cognition. Fellow travelers or partners in crime?.- Frailty and Orthogeriatrics: Enhancing Care for Fragility Fractures.- Frailty in Older Adults with Obesity and the Effect of Lifestyle Interventions.- Vaccines, vaccine-preventable diseases, and frailty.- Oral Health and Frailty.- Perioperative, surgical, and procedural care for older adults with frailty.- Delirium.- Part 7 - Social and Other Issues.- Social Determinants of Physical Frailty.- Educating and Training the Workforce.- Frailty in Low- and Middle-Income Countries.- Ethical and Policy Aspects of Frailty.