Handbook of Juvenile Idiopathic Arthritis

Introduction Disease overviewEpidemiologyEtiology and pathogenesisEnvironmental factorsGenetic susceptibilityRole of humoral and cell-mediated immunityPathogenesis of systemic arthritisPathophysiology of macrophage activation syndrome
Disease classification Classification criteria Challenges in classification
Clinical manifestations Systemic arthritis Rheumatoid factor-negative polyarthritis Rheumatoid factor-positive polyarthritis Oligoarthritis Enthesitis-related arthritis Psoriatic arthritis Undifferentiated arthritis 
Diagnosis Clinical assessment Imaging Biomarkers Differential diagnosis
Consequences and complications Disease course of different subtypes Skeletal and growth abnormalities Ophthalmologic complications Macrophage activation syndrome 
General treatment aspectsGoals of treatment Measuring treatment response Treatment recommendations A multidisciplinary approach to treatment Special considerations in the pediatric patient 
Management of patients with juvenile idiopathic arthritis Psychosocial factors Physical therapy Other non-pharmacologic interventions Non-steroidal anti-inflammatory drugs Intra-articular corticosteroids Systemic corticosteroids Conventional disease-modifying anti-rheumatic drugs Biologic disease-modifying anti-rheumatic drugs Safety of biologics Other pharmacologic interventions Management of iridocyclitis Management of macrophage activation syndrome 
Specific issues Health-related quality of life Vaccination Treatment discontinuation after disease remissionTransition to adult care
Outcome, prognosis and future outlook Long-term outcome and its prediction Mortality Future outlook