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Chromosomal Translocations and Genome Rearrangements in Cancer

Gebonden Engels 2015 9783319199825
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible.

The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics.

Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours.

Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.

Specificaties

ISBN13:9783319199825
Taal:Engels
Bindwijze:gebonden
Uitgever:Springer International Publishing

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Inhoudsopgave

<p>Part I Introduction&nbsp;</p><p>Chapter 1 -&nbsp; A short history of chromosome rearrangements and gene fusions in cancer<br>Felix Mitelman&nbsp;</p><p>Part II General&nbsp;</p><p>Chapter 2 Molecular genetics methods in discovery of chromosome structure<br>Donna Albertson</p><p>Chapter 3 Mechanism of recurrent chromosomal translocations<br>Fred Alt, Richard Frock, Jiazhi Hu<br></p><p>Chapter 4 Chromosome translocations, cancer initiation and clonal evolution</p><p>Mel Greaves, Anthony M Ford&nbsp;</p><p>Chapter 5 Chromosomal fragile sites and cancer<br>Michelle LeBeau, Yanwen Jiang, Isabelle Lucas</p><p>Chapter 6 Copy number changes in carcinomas: applications<br>Pamela Rabbitts, Henry Wood&nbsp;</p><p>Part III LEUKAEMIA/LYMPHOMA&nbsp;</p><p>Chapter 7&nbsp; Chronic myeloid leukaemia<br>Junia Melo, Debora A Casolari</p><p>Chapter 8 Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis<br>P. Leif Bergsagel, W.Michael Kuehl&nbsp;</p><p>Chapter 9 Genetic alterations in B cell lymphoma<br>Riccardo Dalla Favera, Marco Fangazio, Laura Pasqualucci&nbsp;</p><p>Chapter 10 Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia<br>Tom Look, Marc Mansour</p><p>Chapter 11 Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies<br>Chi Wai Eric So, Bernd Zeisig&nbsp;</p><p>Chapter 12 Acute promyelocytic leukaemia:&nbsp; from a specific translocation to cure by targeted therapies<br>Hugues de The, Kim Rice&nbsp;</p><p>Chapter 13 Chromosome Abnormalities in AML and their clinical importance<br>Clara Bloomfield, Krzysztof Mrozek</p><p>PART IV SARCOMAS</p><p>Chapter 14 Fusion Oncogenes of Sarcomas<br>Pierre Aman</p><p>Chapter 15 Translocations in Ewing Sarcoma<br>Stephen L Lessnick, Jason M Tanner</p><p>PART V EPITHELIAL TUMOURS&nbsp;</p><p>Chapter16 RET and thyroid carcinomas<br>Giancarlo Vecchio, Maria Domenica Castellone&nbsp;</p><p>Chapter 17 Gene fusions in prostate cancer<br>Scott Tomlins, A.S.McDaniel&nbsp;</p><p>Chapter 18 Chromosomal Translocations in Lung Cancer<br>Hiroyuki Mano</p><p>Chapter 19 Colon & Ovarian translocations<br>Paul T. Spellman&nbsp;</p><p>PART VI OTHER ASPECTS&nbsp;</p><p>Chapter 20 Pre-clinical modeling of chromosomal translocations and inversions<br>Terry Rabbitts, Katia Ruggero&nbsp;</p><p>Chapter 21 Protein complex hierarchy & translocation gene products<br>Jacqueline Matthews</p><p>Chapter 22 Aberrant transcriptional programming in blood cancers<br>Constanze Bonifer, Peter N. Cockerill, Anetta Ptasinska</p><p>Index</p><p>&nbsp;</p>

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        Chromosomal Translocations and Genome Rearrangements in Cancer