Amyloid and Related Disorders

Introduction/general.- Aspects of the history and nomenclature of amyloid and amyloidosis.- Amyloid diseases at the molecular level: general overview and focus on AL amyloidosis.- AA amyloidosis.- Non-Immunoglobulin and non-AA amyloidoses.- The hereditary amyloidoses.- Dialysis-associated amyloidosis.- Localized amyloidoses and amyloidoses associated with aging outside the central nervous system.- Central nervous system amyloid.- Non-amyloid protein deposits.- Differential diagnosis of amyloid in surgical pathology: organized deposits and other material in the differential diagnosis of amyloidosis.- Light /heavy chain deposition disease as a systemic disease.- Glomerulonephritis with non-organized monoclonal immunoglobulin deposits.- Pathologies of renal and systemic intracellular paraprotein storage: crystalopathies and beyond.- Diagnosis.- Diagnosis of amyloid using Congo red – polarized and fluorescence.- Thioflavin T stain for amyloid detection.- Fat tissue analysis in the management of patients with systemic amyloidosis.- Generic diagnosis of amyloid – recent developments and summary of current recommendations.- Amyloid typing on formalin-fixed paraffin sections by immunohistochemistry – experience from two large referral centers.- Options for amyloid typing in renal pathology – the advantages of frozen section immunofluorescence.- Amyloid typing by immuno-electron microscopy.- Classification of amyloidosis by mass spectrometry-based proteomics.- Summary and practical recommendation regarding amyloid typing using antibody-based and proteomic methods.- Ancillary studies of amyloidosis.- Laboratory support for diagnosis of amyloidosis.- Bone marrow biopsy and its utility in the diagnosis of AL amyloidosis and other plasma cell dyscrasias.- Molecular methods for the diagnosis of hereditary amyloidosis.- Radiologic support for diagnosis and monitoring of amyloidosis – established techniques and recent developments.- Organ involvement inamyloidoses.- Amyloidoses of the Kidney and Genitourinary tract.- Cardiac amyloidosis.- Amyloidosis of the Gastrointestinal tract and Liver.- Peripheral nerve amyloidosis.- Amyloidoses of the Pulmonary and upper respiratory tract.- Amyloidoses involving the skin.- Clinical issues and therapy.- Clinico-pathologic issues in patients with amyloidosis.- Solid organ transplantation in amyloidosis and issues pertaining to domino liver transplantation.- Emerging therapies for amyloidosis.- Clinical trials.- Modern therapies in AA amyloidosis.- Medico legal issues of amyloidosis.- Amyloidosis from the patient’s perspective.