Long Non-coding RNAs in Human Disease

Paperback Engels 2018 9783319795515
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Samenvatting

This
volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives
on the development of
personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Specificaties

ISBN13:9783319795515
Taal:Engels
Bindwijze:Paperback
Aantal pagina's:262
Uitgever:Springer International Publishing

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Inhoudsopgave

Understanding
the Complex Circuitry of lncRNAs at the X-inactivation Center and its
Implications in Disease Conditions.- Long Non-coding RNA ANRIL and Polycomb in
Human Cancers and Cardiovascular Disease.- Form and function of exosome
associated long non-coding RNAs in cancer.- Long Non-coding RNAs in Lung Cancer.-
Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease.- Functional
long non-coding RNAs in vascular smooth muscle cells.- Long Non-coding RNAs as
Targets and Regulators of Nuclear Hormone Receptors.- Non-coding
transcriptional landscape in human aging.- LncRNAs in stress response.- Expression
Specificity of Disease-Associated lncRNAs: towards Personalized Medicine.

 

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          Long Non-coding RNAs in Human Disease