Giancarlo Colombo
GABAB Receptor
Paperback Engels 2018 9783319834283
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.
Specificaties
ISBN13:9783319834283
Taal:Engels
Bindwijze:paperback
Uitgever:Springer International Publishing
Serie:The Receptors
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Inhoudsopgave
<p>1. Historical Perspectives on the GABA<sub>B</sub> Receptor.- Section 1. Chemistry.- 2. Chemistry of GABA<sub>B</sub> Receptor Ligands: Focus on Agonists and Antagonists.- 3. Chemistry of GABA<sub>B</sub> Receptor Ligands: Focus on Positive Allosteric Modulators.- Section 2. Molecular Biology, Biochemistry, & Physiology.- 4. Molecular Structure and Trafficking of the GABA<sub>B</sub> Receptor.- 5. Distribution and Localization of the GABA<sub>B</sub> Receptor.- 6. Activation Mechanism and Allosteric Properties of the GABA<sub>B</sub> Receptor.- 7. Modulation of Neurotransmission by the GABA<sub>B</sub> Receptor.- 8. GABA<sub>B</sub> Receptor Functions In The Mesolimbic Dopamine System.- Section 3. Pharmacology.- 9. Drug Discrimination Studies for Investigations on the Mechanisms of Action of GABA<sub>B</sub> Receptor Ligands.- 10. Targeting the GABA<sub>B</sub> Receptor for the Treatment of Epilepsy.- 11. Targeting the GABA<sub>B</sub> Receptor for the Treatment of Pain.- 12. Targeting the GABA<sub>B</sub> Receptor for the Treatment of Psychiatric Disorders.- 13. Targeting the GABA<sub>B</sub> Receptor for the Treatment of Fragile X Syndrome and Autism Spectrum Disorders.- 14. Targeting the GABA<sub>B</sub> Receptor for the Treatment of Substance Use Disorder.- 15. Targeting the GABA<sub>B</sub> Receptor for the Treatment of Alcohol Use Disorder.- 16. Targeting GABA<sub>B</sub> Receptors for the Treatment of Gastroesophageal Reflux Disease and Chronic Cough.- 17. Baclofen: Therapeutic Use and Potential of the Prototypic GABA<sub>B</sub> Receptor Agonist.- 18. Allosteric Modulators: The New Generation of GABA<sub>B</sub> Receptor Ligands.- 19. GABA<sub>B</sub> Receptor Antagonists as Cognition Enhancers.</p>
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