Endocytosis and Signaling
Gebonden Engels 2018 9783319967035Samenvatting
This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output.
In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.
Specificaties
Lezersrecensies
Inhoudsopgave
Ian Prior and Christophe Lamaze
Chapter 1 The endosomal network: mediators and regulators of endosome maturation
Maria Podinovskaia, Anne Spang
Chapter 2 Integration of the endocytic system into the network of cellular functions
Noga Budick-Harmelin, Marta Miaczynska
Chapter 3 GTPases Rac1 and Ras signaling from endosomes
Francesc Tebar, Carlos Enrich, Carles Rentero,Thomas Grewal
Chapter 4 ESCRT and membrane protein ubiquitination
Simona M. Migliano, David Teis
Chapter 5 Retromer and it’s role in regulating signaling at endosomes
Matthew N.J. Seaman
Chapter 6 The lysosome and intracellular signaling
Geoffrey G. Hesketh, Lena Wartosch, Luther J. Davis, Nicholas A. Bright, J. Paul Luzio
Chapter 7 Interplay of endocytosis and growth factor receptor signaling
Rachel Moore, Marta Giralt Pujol, Zhou Zhu, Elizabeth Smythe
Chapter 8 Role of the endocytosis of caveolae in intracellular signaling and metabolism
Olivia Muriel, Miguel Sánchez-Álvarez, Raffaele Strippoli, Miguel Angel del Pozo
Chapter 9 EGFR trafficking in physiology and cancer
Giusi Caldieri, Maria Grazia Malabarba, Pier Paolo Di Fiore, Sara Sigismund
Chapter 10 Evolving view of membrane trafficking and signaling systems for G protein-coupled receptors
Silvia Sposini, Aylin C. Hanyaloglu
Chapter 11 Endosomal trafficking during mitosis and Notch-dependent asymmetric division
Alicia Daeden, Marcos Gonzales-Gaitan
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