J. Venitz,
W. Sittner
Appropriate Dose Selection - How to Optimize Clinical Drug Development
Gebonden Engels 2006 2007e druk 9783540278672Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers – based on the (known) pharmacology of the drug and/or biology of the underlying disease – along with exposure–response evaluation throughout all phases of drug development can quantitatively integrate clinical pharmacology knowledge, provide early proof of concept, and help in rational dose selection and rational drug product labeling for clinical use.
Specificaties
ISBN13:9783540278672
Taal:Engels
Bindwijze:Gebonden
Aantal pagina's:222
Uitgever:Springer Berlin Heidelberg
Druk:2007
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