Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

Paperback Engels 2015 9783642429361
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.

Specificaties

ISBN13:9783642429361
Taal:Engels
Bindwijze:paperback
Uitgever:Springer Berlin Heidelberg

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Inhoudsopgave

<p>The Origin of Hepatitis C Virus</p><p>Peter Simmonds</p><p> </p><p>Cell Culture Systems for Hepatitis C Virus</p><p>Eike Steinmann and Thomas Pietschmann</p><p> </p><p>Animal Models for Hepatitis C</p><p>Eva Billerbeck, Ype de Jong, Marcus Dorner, Cynthia de la Fuente, and Alexander Ploss</p><p> </p><p>Hepatitis C Virus Entry</p><p>Mirjam B. Zeisel, Daniel J. Felmlee, and Thomas F. Baumert</p><p> </p><p>Hepatitis C Virus Proteins: From Structure to Function</p><p>Darius Moradpour and François Penin</p><p> </p><p>Hepatitis C Virus RNA Translation </p><p>Michael Niepmann</p><p> </p><p>Hepatitis C Virus RNA Replication</p><p>Volker Lohmann</p><p> </p><p>Virion Assembly and Release</p><p>Brett D. Lindenbach</p><p> </p><p>Innate Immune Responses to Hepatitis C Virus</p><p>John W. Schoggins and Charles M. Rice</p><p> </p><p>Adaptive Immune Responses in Hepatitis C Virus Infection</p><p>Christoph Neumann-Haefelin and Robert Thimme</p><p> </p><p>Liver Injury and Disease Pathogenesis in Chronic Hepatitis C</p><p>Daisuke Yamane, David R. McGivern, Takahiro Masaki, and Stanley M. Lemon</p><p> </p><p>Hepatitis C Virus-Specific Directly Acting Antiviral Drugs</p><p>Leen Delang, Johan Neyts, Inge Vliegen, Sergio Abrignani, Petra Neddermann, and Raffaele De Francesco</p><p> </p><p>Treatment of Chronic Hepatitis C: Current and Future</p><p>Jean-Michel Pawlotsky</p>

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        Hepatitis C Virus: From Molecular Virology to Antiviral Therapy