Colm Duffy
Heteroaromatic Lipoxin A4 Analogues
Synthesis and Biological Evaluation
Paperback Engels 2014 2012e druk 9783642438929Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
Specificaties
ISBN13:9783642438929
Taal:Engels
Bindwijze:paperback
Aantal pagina's:130
Uitgever:Springer Berlin Heidelberg
Druk:2012
Serie:Springer Theses
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Inhoudsopgave
Introduction.- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues.- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues.- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues.- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines.- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.
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