Behçet’s Disease

I Special Contribution.- Advances in the Immunopathogenesis of Behçet’s Disease.- II Clinical Understanding of Behçet’s Disease.- 1 Introduction.- 1.1 Definition.- 1.2 Synonyms.- 1.3 Other Common Terms.- 1.4 History.- 1.5 Epidemiology.- 2 Etiopathogenesis.- 2.1 Viral Infection.- 2.2 Bacterial Infection.- 2.3 Heat Shock Protein.- 2.4 Environmental Pollution.- 2.5 Autoimmune Theory.- 2.6 Immunogenetics.- 2.6.1 Familial Occurrence.- 2.6.2 Immunogenetic Aspect.- 3 Clinical Manifestations.- 3.1 Major and Minor Symptoms.- 3.1.1 Occurrence.- 3.1.2 Initial Manifestations.- 3.2 Oral Ulcers.- 3.2.1 Clinical Manifestations.- 3.2.2 Clinical Course of Oral Ulcers.- 3.2.3 Experimentally Induced Oral Ulcers.- 3.2.4 Sequelae from Recurrent Episodes of Oral Ulcers.- 3.2.5 Pediatric Oral Ulcers.- 3.2.6 Prognosis of Recurrent Oral Ulcers.- 3.3 Genital Ulcers.- 3.3.1 Clinical Features.- 3.3.2 Clinical Course of Genital Ulcers.- 3.3.3 Other Urogenital Features.- 3.4 Cutaneous Manifestations.- 3.4.1 Clinical Features.- 3.5 Ocular Manifestations.- 3.5.1 Clinical Features.- 3.5.2 Clinical Course.- 3.5.3 Pediatric Ocular Manifestations.- 3.5.4 Prognosis.- 3.6 Joint Manifestations.- 3.6.1 Clinical Features.- 3.6.2 Clinical Course.- 3.6.3 Joint Involvement in Pediatric Patients.- 3.6.4 Operative Findings.- 3.7 Gastrointestinal Involvement.- 3.8 Vascular Manifestations.- 3.9 Neurologic and Psychiatric Manifestations.- 3.9.1 Clinical Features.- 3.9.2 Clinical Progress.- 3.10 Other Organ Manifestations.- 3.11 Pregnancy-Associated Manifestations.- 4 Diagnosis.- 4.1 Diagnostic Criteria.- 4.2 Pathergy (Skin Hyperreactivity).- 4.3 Laboratory Findings.- 4.4 Differential Diagnosis.- 5 Immunologic Aspects.- 5.1 Cell-Mediated Immunity.- 5.1.1 DNCB Responsiveness.- 5.1.2 T and B Cells.- 5.1.3 Antibody-Dependent Cellular Cytotoxicity (ADCC) and Natural Killer (NK) Cells.- 5.1.4 Cytokines.- 5.2 Humoral Immunity.- 5.2.1 Serum Immunoglobulins.- 5.2.2 Circulating Immune Complexes.- 5.2.3 Autoantibodies.- 6 Histopathology.- 6.1 Characteristics.- 6.2 Light Microscopic Findings.- 6.3 Electron Microscopic Findings.- 7 Interdepartmental Cooperation Approach System.- 8 Therapy.- 9 Prognosis.- 10 Prevention.- 11 Animal Models.- 11.1 Environmental Pollution.- 11.2 HLA-B51.- 11.3 Heat Shock Protein.- 11.4 Herpes Simplex Virus Infection.- Appendix Special issue on Behçet’s Disease of Yonsei Medical Journal (Vol 38, No. 6, December 1997).- Appendix 1 Life Story of Dr. Hûlusi Behçet.- Appendix 2 Molecular Genetics (HLA) of Behçet’s Disease.- Appendix 3 Behçet’s Disease Etiopathology: Immunological Aspects*.- Appendix 4 Etiopathology of Behçet’s Disease: Herpes Simplex Virus Infection and Animal Model.- Appendix 5 Diagnostic Criteria of Behçet’s Diesease: Problems and Suggestions.- Appendix 6 Recurrent Aphthous Stomatitis in the Diagnosis of Behçet’s Disease*.- Appendix 7 Dermatologic Manifestation of Behçet’s Disease.- Appendix 8 Ophthalmologic Manifestations of Behçet’s Disease.- Appendix 9 Behçet’s Disease — A Rheumatologic Perspective.- Appendix 10 Treatment of Behçet’s Disease.- Appendix 11 Adamantiades-Behçet’s Disease: Epidemiology in Germany and in Europe*.- Appendix 12 Clinical Manifestations of Behçet’s Disease: An Analysis of 2147 Patients*.- Appendix 13 Epidemiological and Clinical Features of Behçet’s Disease in Korea.- Appendix 14 The Influence of Pregnancy on Behçet’s Disease.- Appendix 15 Immunological Aspects of Hyperreactivity to Streptococcal Antigens in Behçet’s Disease*.- Appendix 16 Surgical Treatment of Intestinal Behçet’s Disease.