Endothelin and Its Inhibitors

1. Historical Perspective and Introduction to the Endothelin Family of Peptides 2. Sarafotoxins and their Relationship to the Endothelin Family of Peptides 3. Identity of Endothelin-Converting Enzyme and Other Targets for the Therapeutic Regulation of Endothelin Biosynthesis 4. Endothelin Receptors 5. Cell Signalling by Endothelin Peptides 6. Lessons from Gene Deletion of Endothelin Systems 7. Endothelin-Converting Enzyme Inhibitors and Their Effects 8. Endothelin-Converting Enzymes and Endothelin Receptor Localisation in Human Tissues 9. Endothelin Receptor Antagonists 10. Toxicology of Endothelin Receptor Antagonists 11. Endothelins and the Release of Autacoids 12. The Role of Endothelins in Proliferation, Apoptosis and Angiogenesis 13. The Involvement of Endothelins in Cerebral Vasospasms and Stroke 14. Involvement of Endothelins in Airway Reactivity and Disease 15. Endothelin-1 and Pulmonary Hypertension 16. Vascular and Cardiac Effects of Endothelin 17. Endothelins within the Liver and the Gastrointestinal System 18. Endothelin and the Kidney 19. Endothelin Ligands and their Experimental Effects within the Human Circulation