Risk and Progression Factors in Carcinogenesis

I. Interaction of Carcinogens with Cellular DNA.- Induction of Frameshift Mutations at Hotspot Sequences by Carcinogen Adducts.- Oxidative DNA Damage Induced by Dioxetanes, Photosensitizing Ketones, and Photo-Fenton Reagents.- Oxidative DNA Damage Profiles in Mammalian Cells.- Chemical Mechanisms of Formation of DNA-Carcinogen Adducts, Elucidation of Potential of Adducts for Mutagenicity, and Mechanisms of Polymerase Fidelity and Mutation in the Presence of Adducts.- Assessment of the Tumor-Initiating Potential of ?,?-Unsaturated Carbonyl Compounds by 32P Postlabeling Quantification of DNA Adducts In Vivo.- Glutathione-Dependent Bioactivation and Renal Toxicity of Xenobiotics.- Ultraviolet-Induced Photolesions: Repair and Mutagenesis.- Psoralen Photobiology: The Relationship Between DNA Damage, Chromatin Structure, Transcription, and Immunogenic Effects.- II. Analysis of Cellular Alterations and Growth Dysregulation in Cancer Cells.- Cellular Stress Response: Stress Proteins — Physiology and Implications for Cancer.- Two-Dimensional Polyacrylamide Gel Electrophoresis of Cancer-Associated Proteins.- Mechanisms Leading to the Expression of Recessive Alleles: The Use of Polymorphic Microsatellites and Whole-Chromosome Painting Probes to Analyze Mouse Tumors, Mtants, and Micronuclei.- Formation of Micronuclei and Inhibition of Topoisomerase II in the Comet Assay in Mammalian Cells with Altered DNA Methylation.- Poly(ADP-Ribosyl)ation and Nuclear Matrix/Intermediate Filament Proteins in Renal Carcinogenesis.- Genotoxic and Chronic Toxic Effects in the Carcinogenicity of Aromatic Amines.- Analysis of Genetic Factors and Molecular Mechanisms in the Development of Hereditary and Carcinogen-Induced Tumors of Xiphophorus.- The Role of Raf Kinases in Development and Growth of Tumors.- Apoptosis Regulation by Raf, Bcl-2, R-Ras.- New Cell Cycle-Regulated Genes in the Yeast Saccharomyces cerevisiae.- The Role of Workhorse Protein Kinases in Coordinating DNA Metabolism and Cell Growth.- III. Selected Findings in Human Tumors.- Growth and Transformation of Human Oral Epithelium In Vitro.- Genetic Lesions in Mantle Cell Lymphoma.- Topoisomerase Activities in Undifferentiated Acute Myeloblastic Leukemias and Monocytic Differentiated Leukemias.- DNA Repair: Genes, Enzymes, Patients, and Mouse Models.- Repair of Directly and Indirectly UV-Induced DNA Lesions and of DNA Double-Strand Breaks in Cells from Skin Cancer-Prone Patients with the Disorders Dysplastic Nevus Syndrome or Basal Cell Nevus Syndrome.- Exploring the Role of Oxygen in Fanconis Anemia.- P53 Gene Alterations in Human Tumors: Perspectives for Cancer Control.