Cholecystokinin Antagonists in Gastroenterology

I: Biology of CCK.- Biochemistry of CCK.- The Morphological Localization of Cholecystokinin and Its Binding-Sites in the Diffuse Neuroendocrine System.- Heterogeneity of CCK Receptors: Classification and Characterization.- Biological Actions of CCK in the Gastrointestinal Tract.- Biological Actions of CCK in the Central Nervous System.- Vagally Mediated Actions of CCK.- II: Chemistry of CCK Antagonists.- Pentanoic Acid Derivatives.- Characterization of MK-329.- Boc-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-2-Phenylethyl Ester — JMV180: A Unique CCK Analogue with Different Actions on High- and Low-Affinity CCK Receptors.- III: Physiological Application of CCK Antagonists.- Cholestokinin Receptor Antagonists In Vitro.- Effects of Cholecystokinin Receptor Antagonists in Animal Models.- Role of Cholecystokinin in Regulating Gallbladder Contraction and Pancreatic Secretion in Man: Studies with Loxiglumide.- Effect of MK-329 on Pancreatic Secretion in Man.- Regulation of Gallbladder Contraction and Gastric Emptying by the CCK Receptor Antagonist MK-329.- Regulation of CCK Release by Bile Acids.- Pyloric Cholecystokinin Receptors.- Effects of CCK Antagonists on Intestinal Motility in Dogs.- The Role of CCK and CCK Antagonists in Human Esophageal and Gastroduodenal Motility.- Regulation of Gastrointestinal and Colonic Transit by CCK Antagonists.- The Role of CCK in Tumor Growth.- IV: Clinical Potentials of CCK Antagonists.- Experimental Pancreatitis.- Cholecystokinin-Receptor Antagonists in Experimental Pancreatic Tumor Growth.- Efficient Treatment of Biliary Colics with Loxiglumide.- The Role of CCK in Chronic Constipation.- The Rational Use of CCK Antagonists in Irritable Bowel Syndrome.- Cholecystokinin, Cholecystokinin-Receptor Antagonists and the Sphincter of Oddi.