Activation and Desensitization of Transducing Pathways

Chemotaxis and Chemosensing.- Activation and desensitization in bacterial Chemotaxis.- Adaptation of chemoattractant elicited responses in Dictyostelium discoideum.- The inositolcycle of Dictyostelium discoideum.- Cyclic Nucleotide-Coupled Systems.- Glucagon activates two distinct signal transduction systems in hepatocytes,which leads to the desensitization of G-protein-regulated adenylate cyclase, the phosphorylation and inactivation of Gi-2 and the phosphorylation and stimulation of a specific cyclic AMP phosphodiesterase.- Multiple pathways for glucagon-induced heterologous desensitization of liver adenylyl cyclase.- The mechanisms of luteinizing hormone-induced activation and desensitization of adenylate cyclase.- Role of protein kinases in the desensitization-sensitization of ?-adrenergic receptor and prostaglandin receptor stimulation of adenylyl cyclase.- Direct involvement of the cyclic nucleotide binding sites in the cyclic-nucleotide-induced charge shift of protein kinases.- Inositol Phospholipid-Coupled Systems.- Heterogeneity amongst myo-inositol derivatives: metabolism of second messengers and synthesis of co-signals.- Role of glycosyl-phosphatidylinositols in insulin signaling.- Agonist and guanine nucleotide regulation of P2Y-purinergic receptor-linked phospholipase C.- G-Protein Activation.- Mechanisms involved in G-protein activation by hormone receptors.- Visual Transduction.- Regulation and rapid inactivation of the light induced cGMP phosphodiesterase activity in vertebrate retinal rods.- Auxin-Coupled Systems.- Characterization and modulation of the sensitivity of plant protoplasts to auxin.- The auxin-binding-protein from maize coleoptiles.- Is a GTP-binding protein involved in the auxin-mediated phosphoinositide response on plant cellmembranes?.- Ion Conductance.- Regulation of the desensitization of the acetylcholine nicotinic receptor.- Cellular Systems.- The control of human thyroid cell function, proliferation and differentiation.- Activation of the regulated secretory pathway in neuronal cells during in vitro differentiation.