Automated Peptide Synthesis.- Synthesis of All-D-Isomers in the Bradykinin Series.- The Search for Peptides with Specific Antibradykinin Activity.- Discussion.- Recent Developments in the Chemistry of Gastrin.- The Influence of Substitution or Omission of an Amino Group on the Hypotensive Activity of the C-Terminal Sequences of Eledoisin.- Novel Techniques for the Synthesis of Linear and Cyclic Peptides.- Polypeptides Active on Plain Muscle in the Amphibian Skin.- Isolation, Amino Acid Sequence, and Biological Activity of Phyllokinin (Br adykinyl-Isoleucyl-Tyrosine O- Sulfate), a Bradykinin-like Endecapeptide of the Skin of Phyllomedusa rohdei.- Synthetic Peptides Related to Physalaemin and Eledoisin.- Characterization of Kinins in Wasp Venom.- Studies of Bovine Plasma, Kininogen, Ornitho-kallikrein, and Ornitho-kinin.- Enzymatic Kinin Release from Kininogen and from Low- Molecular Compounds.- The Purification and Some Properties of Two Different Kallidinogens from Human Plasma.- Physiological Influence on the Liberation of Human Plasma Kinin at Low Temperatures.- Purification and Properties of Bradykininogen and of the Bradykinin-Releasing and-Destroying Enzymes in Snake Venom.- Human Salivary Kallikrein and Liberation of Colostrokinin.- Studies of the Specificity of Kinin-Forming Enzymes. The Inhibition of the Kininogenic Activity of Trypsin and Kallikreins by Model Compounds.- Demonstration of the Presence of Two Separate Kinin-Forming Systems in Human and Other Plasma.- Quantitative Studies of Kinin-Releasing Enzymes in Plasma.- Immunologic Studies of Components of the Kallikrein-Kinin System.- Kininogenases, Kininases, and Their Inhibitors.- Inactivation and Potentiation of the Effects of Bradykinin.- The RoleoftheCathepsins in the Inactivation of Plasma Kinins.- The Physiological and Pathological Role of the Kallikrein-Kallidin System.- Kallikrein and Vasodilatation in the Salivary Gland.- Further Experiments on the Role of Human Plasma Kinins as Mediators of Functional Vasodilatation in Glandular Tissues.- Effect of Bradykinin on Submandibular Salivary Gland Permeability.- A Radio Immunoassay for Bradykinin.- Self-Antagonism of Bronchoconstriction Induced by Bradykinin and Angiotensin.- The Effect of Bradykinin and Angiotensin on Ganglionic Transmission.- Polypeptide Receptor Mechanisms: Influence of pH.- Sensitization of Smooth Muscle to the Action of Plasma Kinins by Chymotrypsin.- Potentiation of the Effect of Bradykinin.- Bradykinin- Potentiating Factor.- The Influence of Intra-Arterial Infusions of Synthetic Bradykinin on Flow and Composition of Lymph in Dogs.- The Action of Hypotensive Polypeptides on the Pulmonary Arterial Pressure.- Bradykinin and Pulmonary Vascular Permeability in Isolated Blood-Perfused Rabbit Lungs.- Venoconstriction Induced by Bradykinin in the Rabbit Ear.- Cardiovascular Actions of Physalaemin.- Hemodynamic Effects of Physalaemin and of Some Synthetic Eledoisin and Physalaemin-like Polypeptides.- The Effects of Eledoisin and Bradykinin on the General and Visceral Circulation.- The Effects of Bradykinin and Substance P on the Specialized Ventricular Conducting System of Dog Heart.- Microcirculatory Effects of Polypeptides.- The Proteolytic Process in Pancreatic Disease.- Kinin Formation and Destruction in Fluid Produced by a Strangulated Segment of Ileum in the Rat.- Fibrinolysis and Vasoactive Peptides in Anaphylaxis.- Treatment of Experimental and Human Atherosclerosis with Bradykinin-Antagonist, Pyridinolcarbamate: A Preliminary Report.- Some Physiological and Pathological Roles of Kininogen and Kinins.- Bradykininogen in the Blood of Women During Pregnancy, Labor, and Puerperium.- Pharmacologically Active Peptides in Trypanosome Infections.- Possible Modes of Kinin Formation in Some Pathological States in Man.- Biochemical and Physiologic Studies of the Kinins in Carcinoid Syndrome.- Occurrence of a Polypeptide Biologically Not Distinguishable from Bradykinin in Human Pulmonary Carcinoma.- In Memory of Sir John Gaddum, F.R.S..- Purification of Substance P.- Studies of Substance P.- Substance P in Lipid Extracts of Brain Tissue.- The Role of Release of Acetylcholine in the Gut-Contracting Action of a Brain Polypeptide.- Contribution to the Sedative Action of Substance P.- The Hypotensive Action of Eledoisin in Subjects with Arterial Hypertension.- Remarks.- Trasylol.- Concluding Remarks.- Appendix: Report of the Committee on Nomenclature for Hypotensive Peptides Compiled by M. E. Webster.- Author Index.
