Sabine Stübler
Modelling Proteasome Dynamics in a Bayesian Framework
Paperback Engels 2017 9783658201661Levertijd ongeveer 9 werkdagen
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Samenvatting
Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.
Specificaties
ISBN13:9783658201661
Taal:Engels
Bindwijze:paperback
Uitgever:Springer Fachmedien Wiesbaden
Serie:BestMasters
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Inhoudsopgave
<p>Structure and Function of the Proteasome.- Approaches to Model Proteasome Dynamics.- Comparison of the Dynamics of Proteasome Subtypes.- Inhibitor Influence on the Catalytic Subunits.- Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model .</p> <p> </p>
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