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Thymic Development and Selection of T Lymphocytes

Paperback Engels 2016 9783662511961
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Specificaties

ISBN13:9783662511961
Taal:Engels
Bindwijze:paperback
Uitgever:Springer Berlin Heidelberg

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Inhoudsopgave

<p>Development and Function of Cortical Thymic Epithelial Cells<br/>Kensuke Takada, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase, Yousuke Takahama</p><p> Mechanisms of Thymus Medulla Development and Function<br/>Graham Anderson, Song Baik, Jennifer E. Cowan, Nicholas I. McCarthy, Kyoko Nakamura, Sonia M. Parnell, Andrea J. White, Peter J. L. Lane, Eric J. Jenkinson and William E. Jenkinson</p><p>Self-Peptides in TCR Repertoire Selection and Peripheral T Cell Function<br/>Wan-Lin Lo and Paul M. Allen</p><p>Central Tolerance Induction<br/>Maria L. Mouchess and Mark Anderson</p><p>Trafficking to the Thymus<br/>Shirley Zhang and Avinash Bhandoola </p><p>The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes<br/>Hirokazu Tanaka and Ichiro Taniuchi</p><p></p>

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        Thymic Development and Selection of T Lymphocytes