Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia

Molecular and Cellular Mechanisms Disturbance of Endoplasmic Reticulum Functions – A Key Mechanism Underlying Cell Damage? • Role and Mechanisms of Secondary Mitochondrial Failure • Initiating Mechanisms Involved in the Pathobiology of Traumatically Induced Axonal Injury and Interventions Targeted at Blunting their Progression • Molecular Signals for Glial Activation: Pro- and Anti-Inflammatory Cytokines in the Injured Brain • Mechanical and Excitotoxic Lesion of Motoneurons: Effects of Neurotrophins and Ciliary Neurotrophic Factor on Survival and Regeneration News from Cerebral Ischemia Modelling of the Ischemic Penumbra • The Acute Ischemic Penumbra: Topography, Life Span, and Therapeutic Response • Environmental Influence on Gene Expression and Recovery from Cerebral Ischemia • Neuroprotective Strategies in Nature – Novel Clues for the Treatment of Stroke and Trauma • Glial Cell Swelling – Effect of Hypothermia • The Clot Thickens – Thrombolysis and Combination Therapies • Assessment of brain tissue viability under clinical Circumstances • Heparin-Mediated Extracorporeal LDL/Fibrinogen Precipitation – H.E.L.P. – In Coronary and Cerebral Ischemia Remaining Problems in Severe Head Injury Pediatric Head Injury: What is Unique and Different? • Apolipoprotein E and the Response of the Brain to Injury • System Analysis of Patient Management During the Pre- and Early Clinical Phase in Severe Head Injury • The Frequency, Antecedent Events, and Causal Relationships of Neurologic Worsening Following Severe Head Injury • Neuroprotective Effects of Riluzole in Neurotrauma Models: A Review • Challenges in Translating the Efficacy of Neuroprotective Agents in Experimental Models Into Knowledge of Clinical Benefits in Head Injured Patients