Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

Development of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results.- Use of recombinant human BMP-2 in orthopedic trauma.- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects.- Clinical outcomes using rhBMP-2 in spinal fusion applications.- Bone morphogenetic protein signaling is fine-tuned on multiple levels.- Dissection of bone morphogenetic protein signaling using genome-engineering tools.- Alterations of BMP signaling pathway(s) in skeletal diseases.- Signaling cross-talk by bone morphogenetic proteins.- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development.- The role of bone morphogenetic protein 4 (BMP-4) in tooth development.- Bone morphogenetic protein antagonists and kidney.- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins.- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation.- Bone morphogenetic proteins in cartilage biology.- Systemic administration of bone morphogenetic proteins.